| Literature DB >> 22037043 |
Laure Panassié1, Patrick Borentain, Cyril Nafati, Gilles Bernardin, Barbara Doudier, Vincent Thibault, René Gerolami, Philippe Colson.
Abstract
Fulminant hepatitis has been shown to occur in about 1% of acute hepatitis B virus (HBV) infections, and its mortality rate is nearly 70%. Specific HBV genotypic features have been pointed out in fulminant acute hepatitis B worldwide, but these associations remain controversial. We describe all four primary HBV infections diagnosed in 2008 in our institution in Marseille, southeastern France, including two fatal cases. HBV genotypes were D or E. Precore G1896A HBV mutants were detected in both fatal fulminant primary HBV infections. Hepatitis B surface antigen and hepatitis B e antigen (HBeAg) were negative in two and three cases, respectively, despite HBV DNA detection. Primary HBV infection remains a cause of death in France. The impact of the precore G1896A mutation on the severity of AHB deserves to be assessed in larger studies in this country.Entities:
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Year: 2011 PMID： 22037043 DOI： 10.1016/j.clinre.2011.09.002
Source DB: PubMed Journal: Clin Res Hepatol Gastroenterol ISSN： 2210-7401 Impact factor: 2.947