Literature DB >> 22036041

Evolution in the sensitivity of quantitative HIV-1 viral load tests.

Bryan R Cobb1, Jeffrey E Vaks, Tri Do, Regis A Vilchez.   

Abstract

Significant advancements in molecular diagnostics have been made since the inception and application of PCR-based technologies in clinical diagnostic laboratories and the management of HIV-1 infected patients. More recently, real-time PCR has improved the overall performance of assays used for detecting and quantifying HIV-1 RNA viral load in patients undergoing antiretroviral treatment. The effects of these changes and the interpretations of the HIV-1 viral load results are discussed in this review in the context of the different assays used, the viral dynamics of the HIV-1 virus, and the recent changes to HIV-1 treatment guidelines.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22036041     DOI： 10.1016/j.jcv.2011.09.015

Source DB:  PubMed          Journal:  J Clin Virol        ISSN： 1386-6532            Impact factor:   3.168


  18 in total

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10.  Use of reverse-transcriptase-based HIV-1 viral load assessment to confirm low viral loads in newly diagnosed patients in Switzerland.

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