Literature DB >> 2203301

Investigation of potential interaction of ciprofloxacin with cyclosporine in bone marrow transplant recipients.

H U Krüger1, U Schuler, B Proksch, M Göbel, G Ehninger.   

Abstract

The effect of the 4-quinolone antimicrobial agent ciprofloxacin on the concentration in plasma and the pharmacokinetics of the immunosuppressive agent cyclosporine was studied in 10 bone marrow transplant recipients. There were no statistically or clinically significant changes in cyclosporine trough concentrations or areas under the concentration-time curve following oral doses of 500 mg of ciprofloxacin every 12 h for 4 days. The data suggest a lack of relevant pharmacokinetic interaction of ciprofloxacin with cyclosporine. There was no indication of an enhanced nephrotoxicity for this drug combination.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2203301      PMCID： PMC171756          DOI： 10.1128/AAC.34.6.1048

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Synergistic nephrotoxicity due to ciprofloxacin and cyclosporine.

Authors:  C K Avent; D Krinsky; J K Kirklin; R C Bourge; W D Figg
Journal:  Am J Med       Date:  1988-09       Impact factor: 4.965

2.  The effect of ciprofloxacin on antipyrine metabolism.

Authors:  E Ludwig; E Székely; A Csiba; H Graber
Journal:  J Antimicrob Chemother       Date:  1988-07       Impact factor: 5.790

3.  Possible interaction of ciprofloxacin with cyclosporin A.

Authors:  R A Elston; J Taylor
Journal:  J Antimicrob Chemother       Date:  1988-05       Impact factor: 5.790

4.  Cyclosporine A: a clinical evaluation of drug interactions.

Authors:  I Cockburn
Journal:  Transplant Proc       Date:  1986-12       Impact factor: 1.066

5.  Determination of ciprofloxacin and its 7-ethylenediamine metabolite in human serum and urine by high-performance liquid chromatography.

Authors:  W M Awni; J Clarkson; D R Guay
Journal:  J Chromatogr       Date:  1987-08-07

Review 6.  Cyclosporine drug interactions: a review.

Authors:  N K Wadhwa; T J Schroeder; A J Pesce; S A Myre; C W Clardy; M R First
Journal:  Ther Drug Monit       Date:  1987-12       Impact factor: 3.681

7.  Measurement of cyclosporine in plasma from patients with various transplants: HPLC radioimmunoassay with a specific monoclonal antibody compared.

Authors:  J H McBride; D O Rodgerson; S S Park; A F Reyes
Journal:  Clin Chem       Date:  1989-08       Impact factor: 8.327

Review 8.  Clinical pharmacokinetics of cyclosporin.

Authors:  R J Ptachcinski; R Venkataramanan; G J Burckart
Journal:  Clin Pharmacokinet       Date:  1986 Mar-Apr       Impact factor: 6.447

9.  Multiple-dose pharmacokinetics and safety of ciprofloxacin in normal volunteers.

Authors:  M A Gonzalez; F Uribe; S D Moisen; A P Fuster; A Selen; P G Welling; B Painter
Journal:  Antimicrob Agents Chemother       Date:  1984-11       Impact factor: 5.191

10.  Pharmacokinetics of ciprofloxacin: intravenous and increasing oral doses.

Authors:  T Bergan; S B Thorsteinsson; R Solberg; L Bjornskau; I M Kolstad; S Johnsen
Journal:  Am J Med       Date:  1987-04-27       Impact factor: 4.965
View more
  6 in total

Review 1.  Clinically significant drug interactions with cyclosporin. An update.

Authors:  C Campana; M B Regazzi; I Buggia; M Molinaro
Journal:  Clin Pharmacokinet       Date:  1996-02       Impact factor: 6.447

Review 2.  Clinically significant interactions with drugs used in the treatment of tuberculosis.

Authors:  W W Yew
Journal:  Drug Saf       Date:  2002       Impact factor: 5.606

3.  Mediastinitis due to Nocardia asteroides after cardiac transplantation.

Authors:  F Thaler; B Gotainer; G Teodori; C Dubois; P Loirat
Journal:  Intensive Care Med       Date:  1992       Impact factor: 17.440

Review 4.  Clinical features and management of adverse effects of quinolone antibacterials.

Authors:  J H Paton; D S Reeves
Journal:  Drug Saf       Date:  1991 Jan-Feb       Impact factor: 5.606

Review 5.  Drug interactions with quinolone antibacterials.

Authors:  J R Brouwers
Journal:  Drug Saf       Date:  1992 Jul-Aug       Impact factor: 5.606

Review 6.  Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions.

Authors:  F Pea; M Furlanut
Journal:  Clin Pharmacokinet       Date:  2001       Impact factor: 5.577
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.