OBJECTIVES: The purpose of this study was to test the hypothesis that severity of sleep apnea (SA), assessed by frequency of apneas and hypopneas per hour of sleep (apnea-hypopnea index [AHI]), is related to sodium intake in patients with heart failure (HF). BACKGROUND: Dependent edema and overnight rostral fluid shift from the legs correlate with the AHI in patients with HF in whom excessive sodium intake can cause fluid retention. METHODS: Sodium intake was estimated by food recordings in 54 HF patients who underwent overnight polysomnography. RESULTS: Thirty-one of the 54 patients had SA, and their mean sodium intake was higher than that in those without SA (3.0 ± 1.2 g vs. 1.9 ± 0.8 g, p < 0.001). There was a significant correlation between the AHI and sodium intake (r = 0.522, p < 0.001). Multivariate analysis showed that the significant independent correlates of the AHI were sodium intake, male sex, and serum creatinine level. CONCLUSIONS: These findings suggest that in patients with HF, sodium intake plays a role in the pathogenesis of SA.
OBJECTIVES: The purpose of this study was to test the hypothesis that severity of sleep apnea (SA), assessed by frequency of apneas and hypopneas per hour of sleep (apnea-hypopnea index [AHI]), is related to sodium intake in patients with heart failure (HF). BACKGROUND: Dependent edema and overnight rostral fluid shift from the legs correlate with the AHI in patients with HF in whom excessive sodium intake can cause fluid retention. METHODS:Sodium intake was estimated by food recordings in 54 HF patients who underwent overnight polysomnography. RESULTS: Thirty-one of the 54 patients had SA, and their mean sodium intake was higher than that in those without SA (3.0 ± 1.2 g vs. 1.9 ± 0.8 g, p < 0.001). There was a significant correlation between the AHI and sodium intake (r = 0.522, p < 0.001). Multivariate analysis showed that the significant independent correlates of the AHI were sodium intake, male sex, and serum creatinine level. CONCLUSIONS: These findings suggest that in patients with HF, sodium intake plays a role in the pathogenesis of SA.
Authors: Eduardo Pimenta; Michael Stowasser; Richard D Gordon; Susan M Harding; Michel Batlouni; Bin Zhang; Suzanne Oparil; David A Calhoun Journal: Chest Date: 2013-04 Impact factor: 9.410