Literature DB >> 22032400

Advancing drug discovery for schizophrenia.

Stephen R Marder1, Bryan Roth, Patrick F Sullivan, Edward M Scolnick, Eric J Nestler, Mark A Geyer, Daniel R Welnberger, Maria Karayiorgou, Alessandro Guidotti, Jay Gingrich, Schahram Akbarian, Robert W Buchanan, Jeffrey A Lieberman, P Jeffrey Conn, Stephen J Haggarty, Amanda J Law, Brian Campbell, John H Krystal, Bita Moghaddam, Akira Sawa, Akira Saw, Marc G Caron, Susan R George, John A Allen, Michelle Solis.   

Abstract

Sponsored by the New York Academy of Sciences and with support from the National Institute of Mental Health, the Life Technologies Foundation, and the Josiah Macy Jr. Foundation, "Advancing Drug Discovery for Schizophrenia" was held March 9-11 at the New York Academy of Sciences in New York City. The meeting, comprising individual talks and panel discussions, highlighted basic, clinical, and translational research approaches, all of which contribute to the overarching goal of enhancing the pharmaceutical armamentarium for treating schizophrenia. This report surveys work by the vanguard of schizophrenia research in such topics as genetic and epigenetic approaches; small molecule therapeutics; and the relationships between target genes, neuronal function, and symptoms of schizophrenia.
© 2011 New York Academy of Sciences.

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Year:  2011        PMID: 22032400      PMCID: PMC3787879          DOI: 10.1111/j.1749-6632.2011.06216.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN: 0077-8923            Impact factor:   5.691


  19 in total

Review 1.  Animal models of neuropsychiatric disorders.

Authors:  Eric J Nestler; Steven E Hyman
Journal:  Nat Neurosci       Date:  2010-09-27       Impact factor: 24.884

2.  Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia.

Authors:  Akira Sawa; Nicola G Cascella
Journal:  Am J Psychiatry       Date:  2009-02       Impact factor: 18.112

3.  AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.

Authors:  Jen Q Pan; Michael C Lewis; Josh K Ketterman; Elizabeth L Clore; Misha Riley; Keenan R Richards; Erin Berry-Scott; Xiulin Liu; Florence F Wagner; Edward B Holson; Rachael L Neve; Travis L Biechele; Randall T Moon; Edward M Scolnick; Tracey L Petryshen; Stephen J Haggarty
Journal:  Neuropsychopharmacology       Date:  2011-03-09       Impact factor: 7.853

Review 4.  Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.

Authors:  P Jeffrey Conn; Craig W Lindsley; Carrie K Jones
Journal:  Trends Pharmacol Sci       Date:  2008-12-06       Impact factor: 14.819

Review 5.  Akt/GSK3 signaling in the action of psychotropic drugs.

Authors:  Jean-Martin Beaulieu; Raul R Gainetdinov; Marc G Caron
Journal:  Annu Rev Pharmacol Toxicol       Date:  2009       Impact factor: 13.820

6.  Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.

Authors:  Tom Walsh; Jon M McClellan; Shane E McCarthy; Anjené M Addington; Sarah B Pierce; Greg M Cooper; Alex S Nord; Mary Kusenda; Dheeraj Malhotra; Abhishek Bhandari; Sunday M Stray; Caitlin F Rippey; Patricia Roccanova; Vlad Makarov; B Lakshmi; Robert L Findling; Linmarie Sikich; Thomas Stromberg; Barry Merriman; Nitin Gogtay; Philip Butler; Kristen Eckstrand; Laila Noory; Peter Gochman; Robert Long; Zugen Chen; Sean Davis; Carl Baker; Evan E Eichler; Paul S Meltzer; Stanley F Nelson; Andrew B Singleton; Ming K Lee; Judith L Rapoport; Mary-Claire King; Jonathan Sebat
Journal:  Science       Date:  2008-03-27       Impact factor: 47.728

7.  Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.

Authors:  Alessandro Guidotti; Erbo Dong; Marija Kundakovic; Rosalba Satta; Dennis R Grayson; Erminio Costa
Journal:  Trends Pharmacol Sci       Date:  2008-12-26       Impact factor: 14.819

8.  Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.

Authors:  Yingwei Mao; Xuecai Ge; Christopher L Frank; Jon M Madison; Angela N Koehler; Mary Kathryn Doud; Carlos Tassa; Erin M Berry; Takahiro Soda; Karun K Singh; Travis Biechele; Tracey L Petryshen; Randall T Moon; Stephen J Haggarty; Li-Huei Tsai
Journal:  Cell       Date:  2009-03-20       Impact factor: 41.582

9.  mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.

Authors:  Jennifer E Ayala; Yelin Chen; Jessica L Banko; Douglas J Sheffler; Richard Williams; Alexandra N Telk; Noreen L Watson; Zixiu Xiang; Yongqin Zhang; Paulianda J Jones; Craig W Lindsley; M Foster Olive; P Jeffrey Conn
Journal:  Neuropsychopharmacology       Date:  2009-03-18       Impact factor: 7.853

10.  A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia.

Authors:  Stephen J Huffaker; Jingshan Chen; Kristin K Nicodemus; Fabio Sambataro; Feng Yang; Venkata Mattay; Barbara K Lipska; Thomas M Hyde; Jian Song; Dan Rujescu; Ina Giegling; Karine Mayilyan; Morgan J Proust; Armen Soghoyan; Grazia Caforio; Joseph H Callicott; Alessandro Bertolino; Andreas Meyer-Lindenberg; Jay Chang; Yuanyuan Ji; Michael F Egan; Terry E Goldberg; Joel E Kleinman; Bai Lu; Daniel R Weinberger
Journal:  Nat Med       Date:  2009-05-03       Impact factor: 53.440

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  11 in total

1.  Effect of valproic acid on mitochondrial epigenetics.

Authors:  Hu Chen; Svetlana Dzitoyeva; Hari Manev
Journal:  Eur J Pharmacol       Date:  2012-06-20       Impact factor: 4.432

2.  ΔFosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes.

Authors:  David M Dietz; Pamela J Kennedy; Haosheng Sun; Ian Maze; Amy M Gancarz; Vincent Vialou; Ja Wook Koo; Ezekiell Mouzon; Subroto Ghose; Carol A Tamminga; Eric J Nestler
Journal:  Neuropsychopharmacology       Date:  2013-09-26       Impact factor: 7.853

Review 3.  Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target.

Authors:  Na Ye; Bang Li; Qi Mao; Eric A Wold; Sheng Tian; John A Allen; Jia Zhou
Journal:  ACS Chem Neurosci       Date:  2018-12-20       Impact factor: 4.418

Review 4.  Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs.

Authors:  Bryan L Roth
Journal:  Nat Struct Mol Biol       Date:  2019-07-03       Impact factor: 15.369

5.  Schizophrenia research in 2013: are we making progress?

Authors:  Takeshi Sakurai; Leslie A Shinobu; Akira Sawa
Journal:  Neurobiol Dis       Date:  2013-02-01       Impact factor: 5.996

6.  Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model.

Authors:  Francesco Papaleo; Feng Yang; Clare Paterson; Sara Palumbo; Gregory V Carr; Yanhong Wang; Kirsten Floyd; Wenwei Huang; Craig J Thomas; Jingshan Chen; Daniel R Weinberger; Amanda J Law
Journal:  J Neurosci       Date:  2016-04-27       Impact factor: 6.167

Review 7.  Role of social factors on cell death, cerebral plasticity and recovery after stroke.

Authors:  Venugopal Reddy Venna; Louise D McCullough
Journal:  Metab Brain Dis       Date:  2014-04-22       Impact factor: 3.584

8.  Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings.

Authors:  Gabriel S Dichter; Cara A Damiano; John A Allen
Journal:  J Neurodev Disord       Date:  2012-07-06       Impact factor: 4.025

Review 9.  DISC1 as a therapeutic target for mental illnesses.

Authors:  Takatoshi Hikida; Nao J Gamo; Akira Sawa
Journal:  Expert Opin Ther Targets       Date:  2012-11-06       Impact factor: 6.902

Review 10.  GABAergic neuroactive steroids: a new frontier in bipolar disorders?

Authors:  Mauro Giovanni Carta; Krishna M Bhat; Antonio Preti
Journal:  Behav Brain Funct       Date:  2012-12-19       Impact factor: 3.759

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