INTRODUCTION: This study evaluated whether leprosy reactions could be associated with oral infection. METHODS: Leprosy patients (n = 38) with (Group I) and without (Group II) oral infections were selected. Reactions were identified from the clinical and histopathological features associated with serum C-reactive protein (CRP) and10kDa interferon-gamma-induced protein (IP-10) levels, determined before and after elimination of the foci of infection. RESULTS: Group I presented more reactions than group II did, and improvement of the reactions after dental treatment. Serum CRP and IP-10 did not differ before and after the dental treatment, but differed between the groups. CONCLUSIONS: Oral infection could be an exacerbating factor in leprosy reactions.
INTRODUCTION: This study evaluated whether leprosy reactions could be associated with oral infection. METHODS:Leprosypatients (n = 38) with (Group I) and without (Group II) oral infections were selected. Reactions were identified from the clinical and histopathological features associated with serum C-reactive protein (CRP) and10kDa interferon-gamma-induced protein (IP-10) levels, determined before and after elimination of the foci of infection. RESULTS: Group I presented more reactions than group II did, and improvement of the reactions after dental treatment. Serum CRP and IP-10 did not differ before and after the dental treatment, but differed between the groups. CONCLUSIONS:Oral infection could be an exacerbating factor in leprosy reactions.
Authors: Amanda Gabriela de Carvalho; João Gabriel Guimarães Luz; Peter Steinmann; Eliane Ignotti Journal: Rev Inst Med Trop Sao Paulo Date: 2022-06-06 Impact factor: 2.169
Authors: Paulo R L Machado; Lídia M Machado; Mayume Shibuya; Jamile Rego; Warren D Johnson; Marshall J Glesby Journal: PLoS Negl Trop Dis Date: 2015-08-12
Authors: Douglas Eulálio Antunes; Sergio Araujo; Gabriela Porto Ferreira; Ana Carolina Sousa Rodrigues da Cunha; Adeilson Vieira da Costa; Maria Aparecida Gonçalves; Isabela Maria Bernardes Goulart Journal: Mem Inst Oswaldo Cruz Date: 2013-11 Impact factor: 2.743