| Literature DB >> 22030032 |
Timothy J Miles1, Christopher Barfoot, Gerald Brooks, Pamela Brown, Dongzhao Chen, Steven Dabbs, David T Davies, David L Downie, Susanne Eyrisch, Ilaria Giordano, Michael N Gwynn, Alan Hennessy, Jennifer Hoover, Jianzhong Huang, Graham Jones, Roger Markwell, Stephen Rittenhouse, Hong Xiang, Neil Pearson.
Abstract
As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram positive and Gram negative potency. The mechanism of action is via inhibition of bacterial topoisomerases II and IV. We have investigated various subunits in this series and report advanced studies on compound 7 which demonstrates good PK and in vivo efficacy properties.Entities:
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Year: 2011 PMID： 22030032 DOI： 10.1016/j.bmcl.2011.09.114
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823