Literature DB >> 22030029

Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation.

Matthias Glaser1, Julian Goggi, Graham Smith, Matthew Morrison, Sajinder K Luthra, Edward Robins, Eric O Aboagye.   

Abstract

We improved the specific radioactivity of the apoptosis imaging isatin derivative (18)F-ICMT11. We then evaluated (18)F-ICMT11 in EL4 tumor-bearing mice 24h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115±0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083±0.008 SUV). This effect correlated to the observed increases in apoptotic index. Copyright Â
© 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22030029     DOI： 10.1016/j.bmcl.2011.10.001

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Highly efficient click labeling using 2-[¹⁸F]fluoroethyl azide and synthesis of an ¹⁸FN-hydroxysuccinimide ester as conjugation agent.

Authors:  Dong Zhou; Wenhua Chu; Carmen S Dence; Robert H Mach; Michael J Welch
Journal:  Nucl Med Biol       Date:  2012-07-04       Impact factor: 2.408

2.  Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers.

Authors:  Federica Pisaneschi; Lindsay E Kelderhouse; Amanda Hardy; Brian J Engel; Uday Mukhopadhyay; Carlos Gonzalez-Lepera; Joshua P Gray; Argentina Ornelas; Terry T Takahashi; Richard W Roberts; Stephen V Fiacco; David Piwnica-Worms; Steven W Millward
Journal:  Bioconjug Chem       Date:  2017-02-02       Impact factor: 4.774

Review 3.  18 F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.

Authors:  Hema S Krishnan; Longle Ma; Neil Vasdev; Steven H Liang
Journal:  Chemistry       Date:  2017-09-01       Impact factor: 5.236

4.  A Systematic Comparison of 18F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment.

Authors:  Timothy H Witney; Aileen Hoehne; Robert E Reeves; Ohad Ilovich; Mohammad Namavari; Bin Shen; Frederick T Chin; Jianghong Rao; Sanjiv S Gambhir
Journal:  Clin Cancer Res       Date:  2015-05-13       Impact factor: 12.531

5.  Preclinical assessment of carboplatin treatment efficacy in lung cancer by 18F-ICMT-11-positron emission tomography.

Authors:  Timothy H Witney; R Fortt; Robin R Fortt; Eric O Aboagye
Journal:  PLoS One       Date:  2014-03-11       Impact factor: 3.240

Review 6.  Molecular imaging of apoptosis: from micro to macro.

Authors:  Wenbin Zeng; Xiaobo Wang; Pengfei Xu; Gang Liu; Henry S Eden; Xiaoyuan Chen
Journal:  Theranostics       Date:  2015-02-20       Impact factor: 11.556

Review 7.  SPECT and PET radiopharmaceuticals for molecular imaging of apoptosis: from bench to clinic.

Authors:  Xiaobo Wang; Han Feng; Shichao Zhao; Junling Xu; Xinyu Wu; Jing Cui; Ying Zhang; Yuhua Qin; Zhiguo Liu; Tang Gao; Yongju Gao; Wenbin Zeng
Journal:  Oncotarget       Date:  2017-03-21

Review 8.  Avenues to molecular imaging of dying cells: Focus on cancer.

Authors:  Anna A Rybczynska; Hendrikus H Boersma; Steven de Jong; Jourik A Gietema; Walter Noordzij; Rudi A J O Dierckx; Philip H Elsinga; Aren van Waarde
Journal:  Med Res Rev       Date:  2018-03-12       Impact factor: 12.944

9.  Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.

Authors:  Vessela Vassileva; Stephen M Stribbling; Chris Barnes; Laurence Carroll; Marta Braga; Joel Abrahams; Kathrin Heinzmann; Caroline Haegeman; Marion MacFarlane; Kathryn L Simpson; Caroline Dive; Jamie Honeychurch; Timothy M Illidge; Eric O Aboagye
Journal:  EJNMMI Res       Date:  2019-02-19       Impact factor: 3.138

Review 10.  18F-labeling using click cycloadditions.

Authors:  Kathrin Kettenbach; Hanno Schieferstein; Tobias L Ross
Journal:  Biomed Res Int       Date:  2014-05-27       Impact factor: 3.411
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