Literature DB >> 22027096

Bacitracin upregulates mbrAB transcription via mbrCD to confer bacitracin resistance in Streptococcus mutans.

Yoshikazu Mikami1, Naoto Suzuki, Tomihisa Takahashi, Kichibee Otsuka, Hiromasa Tsuda.   

Abstract

Streptococcus mutans is a bacterial cause of dental caries that is resistant to bacitracin. The aim of this study was to elucidate the mbrABCD-related bacitracin resistance mechanism of S. mutans. Transcriptome data demonstrated that the expression levels of 33 genes were induced more than twofold by bacitracin. Fourteen genes were selected from the upregulated genes, and defective mutants of these genes were constructed for measurement of their sensitivity to bacitracin. Among the mutants, only the mbrA- or mbrB-deficient mutants exhibited 100- to 121-fold greater sensitivity to bacitracin when compared with the wild-type strain. Moreover, knockout of the mbrC and mbrD genes abolished the bacitracin-induced mbrAB upregulation. These results suggest that both mbrC and mbrD are required for mbrAB upregulation that confers the bacitracin-resistant phenotype on S. mutans.

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Year:  2011        PMID： 22027096      PMCID： PMC7128243          DOI： 10.1254/jphs.11052sc

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  12 in total

1.  PCR ligation mutagenesis in transformable streptococci: application and efficiency.

Authors:  Peter C Y Lau; Chang Kyoo Sung; Janet H Lee; Donald A Morrison; Dennis G Cvitkovitch
Journal:  J Microbiol Methods       Date:  2002-04       Impact factor: 2.363

2.  Bacitracin: Methods of Production, Concentration, and Partial Purification, with a Summary of the Chemical Properties of Crude Bacitracin.

Authors:  H S Anker; B A Johnson; J Goldberg; F L Meleney
Journal:  J Bacteriol       Date:  1948-02       Impact factor: 3.490

3.  Identification of a fourth gene involved in dTDP-rhamnose synthesis in Streptococcus mutans.

Authors:  Y Tsukioka; Y Yamashita; Y Nakano; T Oho; T Koga
Journal:  J Bacteriol       Date:  1997-07       Impact factor: 3.490

Review 4.  The two-component system. Regulation of diverse signaling pathways in prokaryotes and eukaryotes.

Authors:  C Chang; R C Stewart
Journal:  Plant Physiol       Date:  1998-07       Impact factor: 8.340

Review 5.  Genes involved in bacitracin resistance in Streptococcus mutans.

Authors:  Hiromasa Tsuda; Yoshihisa Yamashita; Yukie Shibata; Yoshio Nakano; Toshihiko Koga
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

6.  Comparative killing kinetics of methicillin-resistant Staphylococcus aureus by bacitracin or mupirocin.

Authors:  E K Chapnick; J D Gradon; B Kreiswirth; L I Lutwick; B C Schaffer; T D Schiano; M H Levi
Journal:  Infect Control Hosp Epidemiol       Date:  1996-03       Impact factor: 3.254

7.  Biological function of the dTDP-rhamnose synthesis pathway in Streptococcus mutans.

Authors:  Y Tsukioka; Y Yamashita; T Oho; Y Nakano; T Koga
Journal:  J Bacteriol       Date:  1997-02       Impact factor: 3.490

8.  Characterization of MbrC involved in bacitracin resistance in Streptococcus mutans.

Authors:  Norio Kitagawa; Susumu Shiota; Yukie Shibata; Toru Takeshita; Yoshihisa Yamashita
Journal:  FEMS Microbiol Lett       Date:  2011-03-01       Impact factor: 2.742

9.  Bacitracin production by a new strain of Bacillus subtilis. Extraction, purification, and characterization.

Authors:  E C Azevedo; E M Rios; K Fukushima; G M Campos-Takaki
Journal:  Appl Biochem Biotechnol       Date:  1993-07       Impact factor: 2.926

10.  Nasal carriage of methicillin-resistant Staphylococcus aureus among surgical unit staff.

Authors:  A Vinodhkumaradithyaa; A Uma; M Shirivasan; I Ananthalakshmi; P Nallasivam; P Thirumalaikolundusubramanian
Journal:  Jpn J Infect Dis       Date:  2009-05       Impact factor: 1.362
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  2 in total

1.  Vitamin D Compounds Are Bactericidal against Streptococcus mutans and Target the Bacitracin-Associated Efflux System.

Authors:  S Saputo; R C Faustoferri; R G Quivey
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

2.  Analysis by confocal laser scanning microscopy of the MDPB bactericidal effect on S. mutans biofilm CLSM analysis of MDPB bactericidal effect on biofilm.

Authors:  Fabíola Galbiatti de Carvalho; Regina Maria Puppin-Rontani; Suzana Beatriz Portugal de Fúcio; Thais de Cássia Negrini; Hugo Lemes Carlo; Franklin Garcia-Godoy
Journal:  J Appl Oral Sci       Date:  2012 Sep-Oct       Impact factor: 2.698
  2 in total

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