| Literature DB >> 22026513 |
Yun Li1, Fang Liang, Qian Li, Yao-chang Xu, Quan-Rui Wang, Lei Jiang.
Abstract
(DHQD)(2)PHAL-catalyzed asymmetric allylic trifluoromethylation of Morita-Baylis-Hillman adducts using a Rupert-Prakash reagent is reported. This transformation provided the S(N)2' trifluoromethylated products with good yields and excellent enantioselectivities at room temperature. It was also found that the reaction could be accelerated using acetonitrile as cosolvent.Entities:
Mesh：
Substances：
Year: 2011 PMID： 22026513 DOI： 10.1021/ol202572u
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005