Literature DB >> 22025054

Transcriptional regulation of macrophage polarization: enabling diversity with identity.

Toby Lawrence1, Gioacchino Natoli.   

Abstract

In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease.

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Year:  2011        PMID： 22025054     DOI： 10.1038/nri3088

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  88 in total

1.  A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

Authors:  Subhra K Biswas; Lisa Gangi; Saki Paul; Tiziana Schioppa; Alessandra Saccani; Marina Sironi; Barbara Bottazzi; Andrea Doni; Bronte Vincenzo; Fabio Pasqualini; Luca Vago; Manuela Nebuloni; Alberto Mantovani; Antonio Sica
Journal:  Blood       Date:  2005-11-03       Impact factor: 22.113

2.  PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties.

Authors:  M Amine Bouhlel; Bruno Derudas; Elena Rigamonti; Rébecca Dièvart; John Brozek; Stéphan Haulon; Christophe Zawadzki; Brigitte Jude; Gérard Torpier; Nikolaus Marx; Bart Staels; Giulia Chinetti-Gbaguidi
Journal:  Cell Metab       Date:  2007-08       Impact factor: 27.287

Review 3.  Alternative activation of macrophages: an immunologic functional perspective.

Authors:  Fernando O Martinez; Laura Helming; Siamon Gordon
Journal:  Annu Rev Immunol       Date:  2009       Impact factor: 28.527

4.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

Authors:  Nathaniel D Heintzman; Rhona K Stuart; Gary Hon; Yutao Fu; Christina W Ching; R David Hawkins; Leah O Barrera; Sara Van Calcar; Chunxu Qu; Keith A Ching; Wei Wang; Zhiping Weng; Roland D Green; Gregory E Crawford; Bing Ren
Journal:  Nat Genet       Date:  2007-02-04       Impact factor: 38.330

5.  PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.

Authors:  C Nerlov; T Graf
Journal:  Genes Dev       Date:  1998-08-01       Impact factor: 11.361

6.  CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.

Authors:  Jeong-Heon Lee; David G Skalnik
Journal:  J Biol Chem       Date:  2005-10-26       Impact factor: 5.157

Review 7.  The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity.

Authors:  Je-In Youn; Dmitry I Gabrilovich
Journal:  Eur J Immunol       Date:  2010-11       Impact factor: 5.532

8.  Control of inducible gene expression by signal-dependent transcriptional elongation.

Authors:  Diana C Hargreaves; Tiffany Horng; Ruslan Medzhitov
Journal:  Cell       Date:  2009-07-10       Impact factor: 41.582

9.  Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

Authors:  Jeong-Heon Lee; David G Skalnik
Journal:  Mol Cell Biol       Date:  2007-11-12       Impact factor: 4.272

10.  Determinants of nucleosome organization in primary human cells.

Authors:  Anton Valouev; Steven M Johnson; Scott D Boyd; Cheryl L Smith; Andrew Z Fire; Arend Sidow
Journal:  Nature       Date:  2011-05-22       Impact factor: 49.962
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  805 in total

Review 1.  Regulation of microglial activation in stroke.

Authors:  Shou-Cai Zhao; Ling-Song Ma; Zhao-Hu Chu; Heng Xu; Wen-Qian Wu; Fudong Liu
Journal:  Acta Pharmacol Sin       Date:  2017-03-06       Impact factor: 6.150

Review 2.  Macrophage polarization and plasticity in health and disease.

Authors:  Subhra K Biswas; Manesh Chittezhath; Irina N Shalova; Jyue-Yuan Lim
Journal:  Immunol Res       Date:  2012-09       Impact factor: 2.829

3.  Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4.

Authors:  Agnieszka J Connor; Jeffrey D Laskin; Debra L Laskin
Journal:  Exp Mol Pathol       Date:  2012-01-24       Impact factor: 3.362

4.  PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice.

Authors:  Tobias Gutting; Christian A Weber; Philip Weidner; Frank Herweck; Sarah Henn; Teresa Friedrich; Shuiping Yin; Julia Kzhyshkowska; Timo Gaiser; Klaus-Peter Janssen; Wolfgang Reindl; Matthias P A Ebert; Elke Burgermeister
Journal:  Oncoimmunology       Date:  2018-02-01       Impact factor: 8.110

Review 5.  MicroRNAs in immune response and macrophage polarization.

Authors:  Gang Liu; Edward Abraham
Journal:  Arterioscler Thromb Vasc Biol       Date:  2013-02       Impact factor: 8.311

6.  AIBP protects against metabolic abnormalities and atherosclerosis.

Authors:  Dina A Schneider; Soo-Ho Choi; Colin Agatisa-Boyle; Laurence Zhu; Jungsu Kim; Jennifer Pattison; Dorothy D Sears; Philip L S M Gordts; Longhou Fang; Yury I Miller
Journal:  J Lipid Res       Date:  2018-03-20       Impact factor: 5.922

7.  Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury.

Authors:  Akihiko Uchiyama; Kazuya Yamada; Buddhini Perera; Sachiko Ogino; Yoko Yokoyama; Yuko Takeuchi; Osamu Ishikawa; Sei-Ichiro Motegi
Journal:  J Invest Dermatol       Date:  2014-12-10       Impact factor: 8.551

Review 8.  Targeting the progression of chronic kidney disease.

Authors:  Marta Ruiz-Ortega; Sandra Rayego-Mateos; Santiago Lamas; Alberto Ortiz; Raul R Rodrigues-Diez
Journal:  Nat Rev Nephrol       Date:  2020-02-14       Impact factor: 28.314

9.  Macrophage molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins are modulated by complement protein C1q.

Authors:  Minh-Minh Ho; Ayla Manughian-Peter; Weston R Spivia; Adam Taylor; Deborah A Fraser
Journal:  Atherosclerosis       Date:  2016-08-22       Impact factor: 5.162

10.  Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis.

Authors:  Xingwei Jiang; Tingting Zhou; Yan Xiao; Jiahui Yu; Shuaijie Dou; Guojiang Chen; Renxi Wang; He Xiao; Chunmei Hou; Wei Wang; Qingzhu Shi; Jiannan Feng; Yuanfang Ma; Beifen Shen; Yan Li; Gencheng Han
Journal:  Oncoimmunology       Date:  2016-08-03       Impact factor: 8.110
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