Literature DB >> 22024846

Efficacy of laryngeal botulinum toxin injection: comparison of two techniques.

Susan L Fulmer1, Albert L Merati, Joel H Blumin.   

Abstract

OBJECTIVES/HYPOTHESIS: It is hypothesized that there is no difference in the effectiveness of botulinum toxin (BTX) injection between electromyography (EMG)-guided and non-EMG guided "point-touch" techniques in the treatment of adductor spasmodic dysphonia. STUDY
DESIGN: Retrospective chart review.
METHODS: Patients selected for evaluation underwent sequential treatment by one or both of the senior authors using two different injection techniques with similar BTX dilution and preparation. Data gathered included dose injected, injection effect, and presence and duration of breathiness and dysphagia after injection. Statistical analysis was performed used a generalized estimating equations model.
RESULTS: A total of 417 injections in 64 patients were analyzed. There was no difference in the rate of successful injections between the EMG-guidance group and the non-EMG guidance group (94.4% and 93.2%, respectively; P = .7).
CONCLUSIONS: This unique study demonstrates that efficacy of BTX does not necessarily depend on the method of injection used. In experienced hands, excellent clinical results can be achieved with either EMG-guided or non-EMG guided injection techniques.
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

Entities:  

Mesh:

Substances:

Year:  2011        PMID: 22024846      PMCID: PMC3202690          DOI: 10.1002/lary.21966

Source DB:  PubMed          Journal:  Laryngoscope        ISSN: 0023-852X            Impact factor:   3.325


  16 in total

Review 1.  Needle EMG guidance for injection of botulinum toxin. Needle EMG guidance is useful.

Authors:  R L Barbano
Journal:  Muscle Nerve       Date:  2001-11       Impact factor: 3.217

Review 2.  Needle EMG guidance for injection of botulinum toxin. Needle EMG guidance is rarely required.

Authors:  J Jankovic
Journal:  Muscle Nerve       Date:  2001-11       Impact factor: 3.217

3.  Sporadic failure of botulinum toxin treatment in usually responsive patients with adductor spasmodic dysphonia.

Authors:  G Galardi; R Guerriero; S Amadio; L Leocani; R Teggi; G Melloni; G Comi
Journal:  Neurol Sci       Date:  2001-08       Impact factor: 3.307

4.  Laryngeal framework surgery in the management of spasmodic dysphonia. Preliminary report.

Authors:  H M Tucker
Journal:  Ann Otol Rhinol Laryngol       Date:  1989-01       Impact factor: 1.547

5.  Localized injections of botulinum toxin for the treatment of focal laryngeal dystonia (spastic dysphonia).

Authors:  A Blitzer; M F Brin; S Fahn; R E Lovelace
Journal:  Laryngoscope       Date:  1988-02       Impact factor: 3.325

6.  Botulinum toxin (BOTOX) for the treatment of "spastic dysphonia" as part of a trial of toxin injections for the treatment of other cranial dystonias.

Authors:  A Blitzer; M F Brin; S Fahn; D Lange; R E Lovelace
Journal:  Laryngoscope       Date:  1986-11       Impact factor: 3.325

7.  Assessment of posterior cricoarytenoid botulinum toxin injections in patients with abductor spasmodic dysphonia.

Authors:  S Bielamowicz; S Squire; K Bidus; C L Ludlow
Journal:  Ann Otol Rhinol Laryngol       Date:  2001-05       Impact factor: 1.547

8.  Indirect laryngoscopic approach for injection of botulinum toxin in spasmodic dysphonia.

Authors:  C N Ford; D M Bless; J D Lowery
Journal:  Otolaryngol Head Neck Surg       Date:  1990-11       Impact factor: 3.497

9.  Quantifying the spread of botulinum toxin through muscle fascia.

Authors:  C M Shaari; E George; B L Wu; H F Biller; I Sanders
Journal:  Laryngoscope       Date:  1991-09       Impact factor: 3.325

Review 10.  Laryngeal electromyography: an evidence-based review.

Authors:  Robert T Sataloff; Steven Mandel; Eric A Mann; Christy L Ludlow
Journal:  Muscle Nerve       Date:  2003-12       Impact factor: 3.217

View more
  2 in total

Review 1.  The Patho-Neurophysiological Basis and Treatment of Focal Laryngeal Dystonia: A Narrative Review and Two Case Reports Applying TMS over the Laryngeal Motor Cortex.

Authors:  Maja Rogić Vidaković; Ivana Gunjača; Josipa Bukić; Vana Košta; Joško Šoda; Ivan Konstantinović; Braco Bošković; Irena Bilić; Nikolina Režić Mužinić
Journal:  J Clin Med       Date:  2022-06-15       Impact factor: 4.964

2.  Botulinum Toxin in Pediatric Neurology: Switching Lanes From Death to Life.

Authors:  Eman M I Moawad; Enas Abdallah Ali Abdallah
Journal:  Glob Pediatr Health       Date:  2015-06-08
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.