| Literature DB >> 22024829 |
Masato Tashiro1, Koichi Izumikawa, Asuka Minematsu, Katsuji Hirano, Naoki Iwanaga, Shotaro Ide, Tomo Mihara, Naoki Hosogaya, Takahiro Takazono, Yoshitomo Morinaga, Shigeki Nakamura, Shintaro Kurihara, Yoshifumi Imamura, Taiga Miyazaki, Tomoya Nishino, Misuzu Tsukamoto, Hiroshi Kakeya, Yoshihiro Yamamoto, Katsunori Yanagihara, Akira Yasuoka, Takayoshi Tashiro, Shigeru Kohno.
Abstract
We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates for itraconazole and posaconazole, respectively. Amphotericin B MICs of ≥2 μg/ml and micafungin minimum effective concentrations (MECs) of ≥16 μg/ml were recorded for two and one isolates, respectively.Entities:
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Year: 2011 PMID： 22024829 PMCID： PMC3256053 DOI： 10.1128/AAC.05394-11
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191