Literature DB >> 2202410

Current status of podophyllotoxin for the treatment of genital warts.

K R Beutner1, G von Krogh.   

Abstract

An evolutionary process that began 50 years ago with a crude plant resin (podophyllum) has currently developed to the point where a fine chemical podophyllotoxin can be safely and effectively applied by patients for the treatment of external genital warts. In this brief review, the fundamental chemistry, pharmacology, and toxicology of podophyllotoxin will be reviewed, along with the sequence of clinical studies that resulted in the development of patient applied podophyllotoxin.

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Year:  1990        PMID： 2202410

Source DB:  PubMed          Journal:  Semin Dermatol        ISSN： 0278-145X


  10 in total

1.  Podophyllum hexandrum modulates gamma radiation-induced immunosuppression in Balb/c mice: implications in radioprotection.

Authors:  H C Goel; H Prakash; A Ali; M Bala
Journal:  Mol Cell Biochem       Date:  2006-10-07       Impact factor: 3.396

Review 2.  What has happened to the cathartic colon?

Authors:  S Müller-Lissner
Journal:  Gut       Date:  1996-09       Impact factor: 23.059

3.  Expression analysis of biosynthetic pathway genes vis-à-vis podophyllotoxin content in Podophyllum hexandrum Royle.

Authors:  Pawan Kumar; Tarun Pal; Neha Sharma; Varun Kumar; Hemant Sood; Rajinder S Chauhan
Journal:  Protoplasma       Date:  2015-01-14       Impact factor: 3.356

4.  Antioxidant activity of fractionated extracts of rhizomes of high-altitude Podophyllum hexandrum: role in radiation protection.

Authors:  Raman Chawla; Rajesh Arora; Raj Kumar; Ashok Sharma; Jagdish Prasad; Surendar Singh; Ravinder Sagar; Pankaj Chaudhary; Sandeep Shukla; Gurpreet Kaur; Rakesh Kumar Sharma; Satish Chander Puri; Kanaya Lal Dhar; Geeta Handa; Vinay Kumar Gupta; Ghulam Nabi Qazi
Journal:  Mol Cell Biochem       Date:  2005-05       Impact factor: 3.396

5.  A highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors.

Authors:  Aniruddha Roy; Mark J Ernsting; Elijus Undzys; Shyh-Dar Li
Journal:  Biomaterials       Date:  2015-03-03       Impact factor: 12.479

6.  Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum.

Authors:  Showkat Ahmad Ganie; Ehtishamul Haq; Abid Hamid; Yasrib Qurishi; Zahid Mahmood; Bilal Ahmad Zargar; Akbar Masood; Mohmmad Afzal Zargar
Journal:  BMC Complement Altern Med       Date:  2011-02-28       Impact factor: 3.659

7.  Self-treatment using 0.25%-0.50% podophyllotoxin-ethanol solutions against penile condylomata acuminata: a placebo-controlled comparative study.

Authors:  G von Krogh; E Szpak; M Andersson; I Bergelin
Journal:  Genitourin Med       Date:  1994-04

8.  Topical treatment of genital warts in men, an open study of podophyllotoxin cream compared with solution.

Authors:  A Strand; R M Brinkeborn; A Siboulet
Journal:  Genitourin Med       Date:  1995-12

9.  Podophyllum hexandrum Offers Radioprotection by Modulating Free Radical Flux: Role of Aryl-Tetralin Lignans.

Authors:  Raman Chawla; Rajesh Arora; Shikha Singh; R K Sagar; Rakesh Kumar Sharma; R Kumar; A Sharma; R P Tripathi; S C Puri; H A Khan; A S Shawl; P Sultan; Tej Krishan; G N Qazi
Journal:  Evid Based Complement Alternat Med       Date:  2006-06-21       Impact factor: 2.629

10.  A polyextremophilic alcohol dehydrogenase from the Atlantis II Deep Red Sea brine pool.

Authors:  Anastassja L Akal; Ram Karan; Adrian Hohl; Intikhab Alam; Malvina Vogler; Stefan W Grötzinger; Jörg Eppinger; Magnus Rueping
Journal:  FEBS Open Bio       Date:  2018-12-18       Impact factor: 2.693
  10 in total

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