| Literature DB >> 22023849 |
Kevin Buyens1, Stefaan C De Smedt, Kevin Braeckmans, Joseph Demeester, Liesbeth Peeters, Leo A van Grunsven, Xavier de Mollerat du Jeu, Rupa Sawant, Vladimir Torchilin, Katarina Farkasova, Manfred Ogris, Niek N Sanders.
Abstract
siRNA therapeutics are currently regarded as promising candidates to make a leap forward in the search for treatments of various hard to cure diseases. In order to exploit the full potential of siRNA based therapeutics, development of delivery systems that can efficiently guide the siRNA molecules to their target without major side effects will be the key to success. Lipid based delivery systems, originating from earlier research in the fields of gene delivery, are the most studied candidates for siRNA delivery. Here we discuss the requirements that need to be met by these siRNA delivery systems to ensure adequate stability after systemic application and subsequent deposition in the target tissue. The encountered hurdles in the blood stream and the solutions proposed in literature are discussed.Entities:
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Year: 2011 PMID： 22023849 DOI： 10.1016/j.jconrel.2011.10.009
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776