BACKGROUND: Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite-impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life. METHODS:High-risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergen-impermeable (n = 416) and placebo mattress covers (n = 394) or no intervention (n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper-responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens. RESULTS: At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms. CONCLUSION: Early intervention with mite-impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization.
RCT Entities:
BACKGROUND: Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite-impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life. METHODS: High-risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergen-impermeable (n = 416) and placebo mattress covers (n = 394) or no intervention (n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper-responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens. RESULTS: At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms. CONCLUSION: Early intervention with mite-impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization.
Authors: Diane R Gold; Gary Adamkiewicz; Syed Hasan Arshad; Juan C Celedón; Martin D Chapman; Ginger L Chew; Donald N Cook; Adnan Custovic; Ulrike Gehring; James E Gern; Christine C Johnson; Suzanne Kennedy; Petros Koutrakis; Brian Leaderer; Herman Mitchell; Augusto A Litonjua; Geoffrey A Mueller; George T O'Connor; Dennis Ownby; Wanda Phipatanakul; Victoria Persky; Matthew S Perzanowski; Clare D Ramsey; Päivi M Salo; Julie M Schwaninger; Joanne E Sordillo; Avrum Spira; Shakira F Suglia; Alkis Togias; Darryl C Zeldin; Elizabeth C Matsui Journal: J Allergy Clin Immunol Date: 2017-05-10 Impact factor: 10.793
Authors: Jesse D Thacher; Ulrike Gehring; Olena Gruzieva; Marie Standl; Göran Pershagen; Carl-Peter Bauer; Dietrich Berdel; Theresa Keller; Sibylle Koletzko; Gerard H Koppelman; Inger Kull; Susanne Lau; Irina Lehmann; Dieter Maier; Tamara Schikowski; Ulrich Wahn; Alet H Wijga; Joachim Heinrich; Jean Bousquet; Josep M Anto; Andrea von Berg; Erik Melén; Henriette A Smit; Thomas Keil; Anna Bergström Journal: Environ Health Perspect Date: 2018-04-12 Impact factor: 9.031
Authors: Frank E van Boven; Nicolette W de Jong; Gert-Jan Braunstahl; Roy Gerth van Wijk; Lidia R Arends Journal: Clin Transl Allergy Date: 2020-01-06 Impact factor: 5.871