Literature DB >> 2202191

Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis.

K Okamoto1, S Hirai, M Shoji, Y Senoh, T Yamazaki.   

Abstract

In 2 of 16 cases with sporadic amyotrophic lateral sclerosis (ALS) large numbers of axonal swellings were observed in the corticospinal tracts over a region extending from the posterior limbs of internal capsules to the bulbar pyramids. On electron microscopy, these axonal swellings were seen to consist of accumulations of neurofilaments and altered neuronal organelles (mitochondria and secondary lysosomes). Their morphology differed from the spheroids seen in the anterior horn in ALS.

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Year:  1990        PMID： 2202191     DOI： 10.1007/bf00308929

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


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Journal:  Neuropathol Appl Neurobiol       Date:  1982 Jul-Aug       Impact factor: 8.090
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  19 in total

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Authors:  Desire D Tshala-Katumbay; Valerie S Palmer; Michael R Lasarev; Robert J Kayton; Mohammad I Sabri; Peter S Spencer
Journal:  Acta Neuropathol       Date:  2006-07-28       Impact factor: 17.088

2.  High signal intensity on T1 weighted MRI of the anterolateral column of the spinal cord in amyotrophic lateral sclerosis.

Authors:  M Waragai; H Shinotoh; M Hayashi; T Hattori
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-01       Impact factor: 10.154

3.  Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-II spectrin.

Authors:  R Kassa; V Monterroso; J Wentzell; A L Ramos; E Couchi; M C Lecomte; M Iordanov; D Kretzschmar; G Nicolas; D Tshala-Katumbay
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Journal:  Protein Cell       Date:  2011-07-12       Impact factor: 14.870

5.  A distinct MR imaging phenotype in amyotrophic lateral sclerosis: correlation between T1 magnetization transfer contrast hyperintensity along the corticospinal tract and diffusion tensor imaging analysis.

Authors:  G Carrara; C Carapelli; F Venturi; M M Ferraris; L Lequio; A Chiò; A Calvo; S Sirgiovanni; A Cistaro; M C Valentini
Journal:  AJNR Am J Neuroradiol       Date:  2011-12-22       Impact factor: 3.825

Review 6.  SOD1 and mitochondria in ALS: a dangerous liaison.

Authors:  Maria Teresa Carrì; Mauro Cozzolino
Journal:  J Bioenerg Biomembr       Date:  2011-12       Impact factor: 2.945

7.  Detection of corticospinal tract compromise in amyotrophic lateral sclerosis with brain MR imaging: relevance of the T1-weighted spin-echo magnetization transfer contrast sequence.

Authors:  Antônio J da Rocha; Acary S B Oliveira; Ricardo B Fonseca; Antônio C M Maia; Renata P Buainain; Henrique M Lederman
Journal:  AJNR Am J Neuroradiol       Date:  2004-10       Impact factor: 3.825

8.  A Drosophila model for TDP-43 proteinopathy.

Authors:  Yan Li; Payal Ray; Elizabeth J Rao; Chen Shi; Weirui Guo; Xiaoping Chen; Elvin A Woodruff; Kazuo Fushimi; Jane Y Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-26       Impact factor: 11.205

9.  New insights into mechanisms of gamma-diketone-induced axonopathy.

Authors:  Desire Tshala-Katumbay; Paul Desjardins; Mohammad Sabri; Roger Butterworth; Peter Spencer
Journal:  Neurochem Res       Date:  2009-04-29       Impact factor: 3.996

10.  Immunocytochemical and ultrastructural studies of upper motor neurons in amyotrophic lateral sclerosis.

Authors:  S Murayama; T W Bouldin; K Suzuki
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088
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