Literature DB >> 2202110

Human globin locus activation region (LAR): role in temporal control.

T M Townes1, R R Behringer.   

Abstract

A region of DNA located far upstream of the human beta-globin locus is critically involved in the regulation of the beta-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.

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Year:  1990        PMID： 2202110     DOI： 10.1016/0168-9525(90)90182-6

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  45 in total

1.  A recurrent intragenic deletion mutation in DSG4 gene in three Pakistani families with autosomal recessive hypotrichosis.

Authors:  Muhammad Arshad Rafiq; Muhammad Ansar; Saqib Mahmood; Sayedul Haque; Muhammad Faiyaz-ul-Haque; Suzanne M Leal; Wasim Ahmad
Journal:  J Invest Dermatol       Date:  2004-07       Impact factor: 8.551

2.  KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.

Authors:  Dewang Zhou; Kaimao Liu; Chiao-Wang Sun; Kevin M Pawlik; Tim M Townes
Journal:  Nat Genet       Date:  2010-08-01       Impact factor: 38.330

3.  Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.

Authors:  Dana N Levasseur; Jianlong Wang; Michael O Dorschner; John A Stamatoyannopoulos; Stuart H Orkin
Journal:  Genes Dev       Date:  2008-02-18       Impact factor: 11.361

Review 4.  Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control.

Authors:  L P Villarreal
Journal:  Microbiol Rev       Date:  1991-09

5.  Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.

Authors:  A P Jarman; W G Wood; J A Sharpe; G Gourdon; H Ayyub; D R Higgs
Journal:  Mol Cell Biol       Date:  1991-09       Impact factor: 4.272

6.  Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.

Authors:  J J Caterina; D Donze; C W Sun; D J Ciavatta; T M Townes
Journal:  Nucleic Acids Res       Date:  1994-06-25       Impact factor: 16.971

7.  Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4.

Authors:  G S Ginsburg; J Ozer; S K Karathanasis
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

8.  High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.

Authors:  T C Dale; M J Krnacik; C Schmidhauser; C L Yang; M J Bissell; J M Rosen
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

9.  Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases.

Authors:  W Zhang; J J Bieker
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

10.  An enhancer/locus control region is not sufficient to open chromatin.

Authors:  M Reitman; E Lee; H Westphal; G Felsenfeld
Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272
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