Christopher L Anderson1, M Camden Whitaker. 1. Department of Surgery, Section of Orthopaedics, The University of Kansas School of Medicine-Wichita, Wichita, KS 67214, USA. canderson2@kumc.edu
Abstract
STUDY DESIGN: A case of heterotopic ossification in the lumbar spine associated with the off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) is reported. OBJECTIVE: To highlight a previously unreported complication of rhBMP-2 use and to review the literature pertinent to the topic. SUMMARY OF BACKGROUND DATA: There is no report in the literature regarding a large mass of rhBMP-2-associated heterotopic ossification surrounding the paraspinal musculature. METHODS: The clinical and radiographical features of this complication and treatment course are presented. RESULTS: The surgical excision of heterotopic ossification and removal of symptomatic instrumentation have resulted in the patient remaining asymptomatic at 1 year of follow-up examination. CONCLUSION: The reported case adds to the literature of off-label use of rhBMP-2 and the potential for the formation of heterotopic ossification with its use.
STUDY DESIGN: A case of heterotopic ossification in the lumbar spine associated with the off-label use of recombinant humanbone morphogenetic protein-2 (rhBMP-2) is reported. OBJECTIVE: To highlight a previously unreported complication of rhBMP-2 use and to review the literature pertinent to the topic. SUMMARY OF BACKGROUND DATA: There is no report in the literature regarding a large mass of rhBMP-2-associated heterotopic ossification surrounding the paraspinal musculature. METHODS: The clinical and radiographical features of this complication and treatment course are presented. RESULTS: The surgical excision of heterotopic ossification and removal of symptomatic instrumentation have resulted in the patient remaining asymptomatic at 1 year of follow-up examination. CONCLUSION: The reported case adds to the literature of off-label use of rhBMP-2 and the potential for the formation of heterotopic ossification with its use.
Authors: Mitchell S Fourman; Eugene W Borst; Eric Bogner; S Robert Rozbruch; Austin T Fragomen Journal: Clin Orthop Relat Res Date: 2013-08-29 Impact factor: 4.176
Authors: Raymond Wing Moon Lam; Sunny Akogwu Abbah; Wang Ming; Mathanapriya Naidu; Felly Ng; Hu Tao; James Goh Cho Hong; Kang Ting; Wong Hee Kit Journal: J Vis Exp Date: 2016-08-22 Impact factor: 1.355
Authors: Jason D Wink; Patrick A Gerety; Rami D Sherif; Youngshin Lim; Nadya A Clarke; Chamith S Rajapakse; Hyun-Duck Nah; Jesse A Taylor Journal: Plast Reconstr Surg Date: 2014-07 Impact factor: 4.730