BACKGROUND: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis. OBJECTIVE: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls. METHODS: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949-2007). Data were linked to the National Hospital Discharge Register (1977-2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls. RESULTS: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33-1.46). In particular, IRRs of tibia fracture (3.36 [2.75-4.11]), femur fracture (6.66 [5.06-8.76]) and hip fracture (3.20 [2.83-3.62]) were elevated in MS patients versus controls. CONCLUSION: Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.
BACKGROUND:Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis. OBJECTIVE: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls. METHODS: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949-2007). Data were linked to the National Hospital Discharge Register (1977-2007). Patients with MS (n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls. RESULTS: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33-1.46). In particular, IRRs of tibia fracture (3.36 [2.75-4.11]), femur fracture (6.66 [5.06-8.76]) and hip fracture (3.20 [2.83-3.62]) were elevated in MS patients versus controls. CONCLUSION:Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.
Authors: Tingting Zhang; Andrew R Zullo; Theresa I Shireman; Yoojin Lee; Vincent Mor; Qing Liu; Kevin W McConeghy; Lori Daiello; Douglas P Kiel; Sarah D Berry Journal: Disabil Health J Date: 2018-03-21 Impact factor: 2.554
Authors: Marloes T Bazelier; Tjeerd-Pieter van Staa; Bernard M J Uitdehaag; Cyrus Cooper; Hubert G M Leufkens; Peter Vestergaard; Joan Bentzen; Frank de Vries Journal: Neurology Date: 2012-08-15 Impact factor: 9.910
Authors: Tina Willson; Scott D Nelson; Jonathan Newbold; Richard E Nelson; Joanne LaFleur Journal: Clin Epidemiol Date: 2015-01-09 Impact factor: 4.790
Authors: Y Nilsagård; H Gunn; J Freeman; P Hoang; S Lord; Rajarshi Mazumder; Michelle Cameron Journal: Mult Scler Date: 2014-06-16 Impact factor: 6.312