AIMS/HYPOTHESIS: Vitamin D insufficiency has not been well studied in Native American (NA) children, who are at risk for obesity and diabetes. The authors examined vitamin D insufficiency and its association with body mass index (BMI) and insulin resistance. METHODS: In a cross-section of NA children 5 to 18 years old (N = 198), anthropometrics, biomarkers of insulin resistance, and 25-hydroxy-vitamin D concentration [25(OH) vitamin D] were measured. BMI% and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. RESULTS: Mean age was 10.8 ± 0.3 years (mean ± SEM). Mean serum 25(OH) vitamin D was 17.8 ± 0.4 ng/mL and 97% had vitamin D insufficiency [25(OH) vitamin D <30 ng/mL]. After adjusting for BMI, 25(OH) vitamin D was inversely associated with HOMA-IR (P < .0001) and several other markers of insulin resistance. CONCLUSIONS/ INTERPRETATION: Vitamin D insufficiency was nearly universal in this cohort of NA children and was associated with diabetes and vascular risk markers. Whether vitamin D supplementation can improve insulin resistance must be studied further.
AIMS/HYPOTHESIS: Vitamin Dinsufficiency has not been well studied in Native American (NA) children, who are at risk for obesity and diabetes. The authors examined vitamin Dinsufficiency and its association with body mass index (BMI) and insulin resistance. METHODS: In a cross-section of NA children 5 to 18 years old (N = 198), anthropometrics, biomarkers of insulin resistance, and 25-hydroxy-vitamin D concentration [25(OH) vitamin D] were measured. BMI% and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. RESULTS: Mean age was 10.8 ± 0.3 years (mean ± SEM). Mean serum 25(OH) vitamin D was 17.8 ± 0.4 ng/mL and 97% had vitamin Dinsufficiency [25(OH) vitamin D <30 ng/mL]. After adjusting for BMI, 25(OH) vitamin D was inversely associated with HOMA-IR (P < .0001) and several other markers of insulin resistance. CONCLUSIONS/ INTERPRETATION:Vitamin Dinsufficiency was nearly universal in this cohort of NA children and was associated with diabetes and vascular risk markers. Whether vitamin D supplementation can improve insulin resistance must be studied further.
Authors: Jennifer M Sacheck; Qiushi Huang; Maria I Van Rompay; Virginia R Chomitz; Christina D Economos; Misha Eliasziw; Catherine M Gordon; Elizabeth Goodman Journal: Am J Clin Nutr Date: 2022-01-11 Impact factor: 7.045
Authors: Jennifer M Sacheck; Maria I Van Rompay; Virginia R Chomitz; Christina D Economos; Misha Eliasziw; Elizabeth Goodman; Catherine M Gordon; Michael F Holick Journal: J Clin Endocrinol Metab Date: 2017-12-01 Impact factor: 5.958