AIMS: To determine whether intensive risk factor management reduced markers of inflammation in middle-aged and older people with type 2 diabetes who either had, or were at risk for cardiovascular disease (CVD), and whether these effects were mediated by adiposity. METHODS: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial was a multicenter double 2 by 2 factorial randomized controlled trial of 10,251 middle-aged and older people who had type 2 diabetes, a GHbA1c of 7.5% or greater, and evidence of CVD or CVD risk factors. Biomarkers were assessed in a subset of 562 participants. Intervention effects on high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were tested using linear regression models. RESULTS: A significantly lower average hs-CRP was noted in the intensive versus the standard glycemic group (p=0.029). Adjusting for change in BMI or waist circumference resulted in larger differences in adjusted hs-CRP (p<0.001 and p<0.002, respectively) between the glycemic intervention groups. CONCLUSIONS: Intensive glycemic control was associated with a reduction in hs-CRP in this study population. Intervention associated increases in adiposity suppressed the beneficial effect of intensive glycemic control on lowering hs-CRP.
RCT Entities:
AIMS: To determine whether intensive risk factor management reduced markers of inflammation in middle-aged and older people with type 2 diabetes who either had, or were at risk for cardiovascular disease (CVD), and whether these effects were mediated by adiposity. METHODS: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial was a multicenter double 2 by 2 factorial randomized controlled trial of 10,251 middle-aged and older people who had type 2 diabetes, a GHbA1c of 7.5% or greater, and evidence of CVD or CVD risk factors. Biomarkers were assessed in a subset of 562 participants. Intervention effects on high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were tested using linear regression models. RESULTS: A significantly lower average hs-CRP was noted in the intensive versus the standard glycemic group (p=0.029). Adjusting for change in BMI or waist circumference resulted in larger differences in adjusted hs-CRP (p<0.001 and p<0.002, respectively) between the glycemic intervention groups. CONCLUSIONS: Intensive glycemic control was associated with a reduction in hs-CRP in this study population. Intervention associated increases in adiposity suppressed the beneficial effect of intensive glycemic control on lowering hs-CRP.
Authors: Marinella Ruospo; Valeria M Saglimbene; Suetonia C Palmer; Salvatore De Cosmo; Antonio Pacilli; Olga Lamacchia; Mauro Cignarelli; Paola Fioretto; Mariacristina Vecchio; Jonathan C Craig; Giovanni Fm Strippoli Journal: Cochrane Database Syst Rev Date: 2017-06-08
Authors: Hetal S Shah; Mario Luca Morieri; Santica M Marcovina; Ronald J Sigal; Hertzel C Gerstein; Michael J Wagner; Alison A Motsinger-Reif; John B Buse; Peter Kraft; Josyf C Mychaleckyj; Alessandro Doria Journal: Diabetes Care Date: 2017-11-28 Impact factor: 19.112
Authors: Irma Isordia-Salas; María Eugenia Galván-Plata; Alfredo Leaños-Miranda; Eberth Aguilar-Sosa; Francisco Anaya-Gómez; Abraham Majluf-Cruz; David Santiago-Germán Journal: J Diabetes Res Date: 2014-03-17 Impact factor: 4.011
Authors: Mario Luca Morieri; Hetal S Shah; Jennifer Sjaarda; Petra A Lenzini; Hannah Campbell; Alison A Motsinger-Reif; He Gao; Laura Lovato; Sabrina Prudente; Assunta Pandolfi; Marcus G Pezzolesi; Ronald J Sigal; Guillaume Paré; Santica M Marcovina; Daniel M Rotroff; Elisabetta Patorno; Luana Mercuri; Vincenzo Trischitta; Emily Y Chew; Peter Kraft; John B Buse; Michael J Wagner; Sharon Cresci; Hertzel C Gerstein; Henry N Ginsberg; Josyf C Mychaleckyj; Alessandro Doria Journal: Diabetes Date: 2020-01-23 Impact factor: 9.461