Literature DB >> 2201921

Stimulation of p21ras upon T-cell activation.

J Downward1, J D Graves, P H Warne, S Rayter, D A Cantrell.   

Abstract

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

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Year:  1990        PMID： 2201921     DOI： 10.1038/346719a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  208 in total

Review 1.  Regulation of integrin function by T cell activation: points of convergence and divergence.

Authors:  T Zell; W J Kivens; S A Kellermann; Y Shimizu
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

2.  Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA.

Authors:  S M Leung; R Rojas; C Maples; C Flynn; W G Ruiz; T S Jou; G Apodaca
Journal:  Mol Biol Cell       Date:  1999-12       Impact factor: 4.138

3.  A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras.

Authors:  K W Lynch; A Weiss
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

4.  Regulation of Ras signaling specificity by protein kinase C.

Authors:  G Rusanescu; T Gotoh; X Tian; L A Feig
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

5.  Ras effector pathway activation by epidermal growth factor is inhibited in vivo by exoenzyme S ADP-ribosylation of Ras.

Authors:  M L Henriksson; R Rosqvist; M Telepnev; H Wolf-Watz; B Hallberg
Journal:  Biochem J       Date:  2000-04-01       Impact factor: 3.857

Review 6.  Regulation of T cell development in the thymus.

Authors:  J Kaye
Journal:  Immunol Res       Date:  2000       Impact factor: 2.829

7.  Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1.

Authors:  J Czyzyk; D Leitenberg; T Taylor; K Bottomly
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

8.  Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway.

Authors:  M C Rouyez; C Boucheron; S Gisselbrecht; I Dusanter-Fourt; F Porteu
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

9.  Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.

Authors:  R R Mattingly; A Sorisky; M R Brann; I G Macara
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Developmental decisions in Aspergillus nidulans are modulated by Ras activity.

Authors:  T Som; V S Kolaparthi
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272
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