| Literature DB >> 2201913 |
G von Poser1, H H Andrade, K V da Silva, A T Henriques, J A Henriques.
Abstract
In the last decade, the possible correlation between the use of reserpine and rauwolfia drugs as antihypertensive agents and breast cancer incidence has been investigated. For the purpose of evaluating the mutagenic and genotoxic effects of these drugs, reserpine and ajmalicine were studied using the SOS Chromotest and the induction of gene conversion, crossing-over and reverse mutation in the yeast diploid strain XS2316. The results indicated a lack of genotoxic, mutagenic and recombinogenic effects.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2201913 DOI： 10.1016/0027-5107(90)90107-f
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433