OBJECTIVE: The aim of the work described here was to characterize quality of life (QOL) and its determinants in a large cohort of adult patients with epilepsy. METHODS: Validated measures reflecting disease severity and psychosocial functioning were electronically collected on all outpatients seen during 2009. Multivariate regression adjusting for repeated measures identified determinants of QOL, as defined by the Quality of Life in Epilepsy Questionnaire-10 (QOLIE-10). RESULTS: Seven thousand seven hundred eighty-four visits from patients with epilepsy were identified. The questionnaire completion rate was 77%, yielding 5960 records corresponding to 1931 individual patients for analysis. Following multivariate modeling, the two most clinically significant QOL predictors were seizure severity (mean QOLIE-10 score=28.8 if LSSS>40 vs 19.2 otherwise) and depression (mean QOLIE-10 score=31.7 if PHQ-9≥10 vs 19.3 otherwise). CONCLUSIONS: Optimizing quality of life in patients with epilepsy requires an approach that extends beyond controlling seizures. Collection of validated health status measures improving patient management is possible within the setting of routine clinical care.
OBJECTIVE: The aim of the work described here was to characterize quality of life (QOL) and its determinants in a large cohort of adult patients with epilepsy. METHODS: Validated measures reflecting disease severity and psychosocial functioning were electronically collected on all outpatients seen during 2009. Multivariate regression adjusting for repeated measures identified determinants of QOL, as defined by the Quality of Life in Epilepsy Questionnaire-10 (QOLIE-10). RESULTS: Seven thousand seven hundred eighty-four visits from patients with epilepsy were identified. The questionnaire completion rate was 77%, yielding 5960 records corresponding to 1931 individual patients for analysis. Following multivariate modeling, the two most clinically significant QOL predictors were seizure severity (mean QOLIE-10 score=28.8 if LSSS>40 vs 19.2 otherwise) and depression (mean QOLIE-10 score=31.7 if PHQ-9≥10 vs 19.3 otherwise). CONCLUSIONS: Optimizing quality of life in patients with epilepsy requires an approach that extends beyond controlling seizures. Collection of validated health status measures improving patient management is possible within the setting of routine clinical care.
Authors: Nobuko Kemmotsu; N Erkut Kucukboyaci; Christopher E Cheng; Holly M Girard; Evelyn S Tecoma; Vicente J Iragui; Carrie R McDonald Journal: Epilepsy Behav Date: 2013-10-28 Impact factor: 2.937
Authors: S Alisha Epps; Kroshona D Tabb; Sharon J Lin; Alexa B Kahn; Martin A Javors; Katherine A Boss-Williams; Jay M Weiss; David Weinshenker Journal: Neuropsychopharmacology Date: 2012-08-08 Impact factor: 7.853
Authors: Jaivir S Rathore; Lara E Jehi; Youran Fan; Sima I Patel; Nancy Foldvary-Schaefer; Maya J Ramirez; Robyn M Busch; Nancy A Obuchowski; George E Tesar Journal: Epilepsy Behav Date: 2014-07-26 Impact factor: 2.937
Authors: Maurizio Pompili; Gianluca Serafini; Marco Innamorati; Franco Montebovi; Dorian A Lamis; Mariantonietta Milelli; Manuela Giuliani; Matteo Caporro; Paolo Tisei; David Lester; Mario Amore; Paolo Girardi; Carla Buttinelli Journal: World J Psychiatry Date: 2014-12-22
Authors: Nobuko Kemmotsu; N Erkut Kucukboyaci; Kelly M Leyden; Christopher E Cheng; Holly M Girard; Vicente J Iragui; Evelyn S Tecoma; Carrie R McDonald Journal: Epilepsy Res Date: 2014-08-30 Impact factor: 3.045