OBJECTIVE: Our study is to investigate somatosensory dysfunction in children with spastic cerebral palsy (CP) using magnetoencephalography (MEG) and synthetic aperture magnetometry (SAM). METHODS: Six children with spastic CP and six age- and gender-matched typically developing children were studied using a 275-channel MEG system while their left and right index fingers were stimulated in random order. The latency and amplitude of somatosensory evoked magnetic fields were analyzed at sensor level. The patterns of high-gamma oscillations were investigated with SAM at source level. RESULTS: In comparison to the children with typical development, the latency of the first response of somatosensory evoked magnetic fields (SEFs) in the children with spastic CP was significantly delayed (p<0.05). High-gamma oscillations were identified in the somatosensory cortex in both children with CP and typical developing children. Interestingly, children with spastic CP had significantly higher incidence of ipsilateral activation in the somatosensory cortex following right and left finger stimulation, compared to typically developing children (p=0.05). CONCLUSION: The results suggest that children with spastic CP have a measurable delay of SEFs and high-gamma oscillations. The high rates of ipsilateral cortical activation imply the impairments of functional lateralization in the developing brain. This is the first MEG study to demonstrate abnormal high-gamma oscillations of somatosensory cortices representing the finger in children with spastic CP.
OBJECTIVE: Our study is to investigate somatosensory dysfunction in children with spastic cerebral palsy (CP) using magnetoencephalography (MEG) and synthetic aperture magnetometry (SAM). METHODS: Six children with spastic CP and six age- and gender-matched typically developing children were studied using a 275-channel MEG system while their left and right index fingers were stimulated in random order. The latency and amplitude of somatosensory evoked magnetic fields were analyzed at sensor level. The patterns of high-gamma oscillations were investigated with SAM at source level. RESULTS: In comparison to the children with typical development, the latency of the first response of somatosensory evoked magnetic fields (SEFs) in the children with spastic CP was significantly delayed (p<0.05). High-gamma oscillations were identified in the somatosensory cortex in both children with CP and typical developing children. Interestingly, children with spastic CP had significantly higher incidence of ipsilateral activation in the somatosensory cortex following right and left finger stimulation, compared to typically developing children (p=0.05). CONCLUSION: The results suggest that children with spastic CP have a measurable delay of SEFs and high-gamma oscillations. The high rates of ipsilateral cortical activation imply the impairments of functional lateralization in the developing brain. This is the first MEG study to demonstrate abnormal high-gamma oscillations of somatosensory cortices representing the finger in children with spastic CP.
Authors: Elina Pihko; Päivi Nevalainen; Selja Vaalto; Kristina Laaksonen; Helena Mäenpää; Leena Valanne; Leena Lauronen Journal: Hum Brain Mapp Date: 2014-02-12 Impact factor: 5.038
Authors: Michael P Trevarrow; Anna Reelfs; Sarah E Baker; Rashelle M Hoffman; Tony W Wilson; Max J Kurz Journal: Sci Rep Date: 2022-03-21 Impact factor: 4.379
Authors: Michael P Trevarrow; Anna Reelfs; Lauren R Ott; Samantha H Penhale; Brandon J Lew; Jessica Goeller; Tony W Wilson; Max J Kurz Journal: Brain Commun Date: 2022-04-04
Authors: Christos Papadelis; Banu Ahtam; Maria Nazarova; Donna Nimec; Brian Snyder; Patricia Ellen Grant; Yoshio Okada Journal: Front Hum Neurosci Date: 2014-09-12 Impact factor: 3.169