BACKGROUND:Topical anesthetics have been used in various procedures. The purpose of this study was to evaluate efficacy of lidocaine/prilocaine cream in decreasing the pain of injection for sentinel lymph node biopsy. METHODS: A prospective, randomized, placebo-controlled study was conducted on female breast cancer patients undergoing periareolar injection for sentinel lymph node isolation. Subjects applied lidocaine/prilocaine cream or a placebo cream before injection and completed a survey postoperatively. RESULTS:Twenty treatment and 19 control patients were studied. There was a trend for control subjects to indicate that the injection was "painful" or "extremely painful" more often than treatment subjects (52.6% vs 25.0%, respectively, P = .074). The treatment group was more likely to recommend the cream to other cancer patients (70.0% vs 42.1%), with a trend toward significance (P = .076). CONCLUSIONS: This study showed no statistically significant reduction in pain scores in subjects receiving the topical anesthetic. Further studies targeting patients with low pain tolerance may prove more effective.
RCT Entities:
BACKGROUND: Topical anesthetics have been used in various procedures. The purpose of this study was to evaluate efficacy of lidocaine/prilocaine cream in decreasing the pain of injection for sentinel lymph node biopsy. METHODS: A prospective, randomized, placebo-controlled study was conducted on female breast cancerpatients undergoing periareolar injection for sentinel lymph node isolation. Subjects applied lidocaine/prilocaine cream or a placebo cream before injection and completed a survey postoperatively. RESULTS: Twenty treatment and 19 control patients were studied. There was a trend for control subjects to indicate that the injection was "painful" or "extremely painful" more often than treatment subjects (52.6% vs 25.0%, respectively, P = .074). The treatment group was more likely to recommend the cream to other cancerpatients (70.0% vs 42.1%), with a trend toward significance (P = .076). CONCLUSIONS: This study showed no statistically significant reduction in pain scores in subjects receiving the topical anesthetic. Further studies targeting patients with low pain tolerance may prove more effective.
Authors: Mickaila J Johnston; James A Ntambi; Nicki Hilliard; Horace J Spencer; Rita Vaughn; Shawna S Owens; Rebecca S Myrick; Larry D Parker; Douglas A Garner; Tracy L Yarbrough Journal: Clin Nucl Med Date: 2015-12 Impact factor: 7.794
Authors: Jonathan T Unkart; Jennifer L Baker; Ava Hosseini; Carl K Hoh; Mark S Wallace; David R Vera; Anne M Wallace Journal: Ann Surg Oncol Date: 2015-08-15 Impact factor: 5.344