| Literature DB >> 22018447 |
Beate Schultheis1, Bart A Nijmeijer, H Yin, Roger G Gosden, Junia V Melo.
Abstract
Imatinib should be avoided in women planning to become pregnant or during pregnancy, due to a higher risk of congenital malformations. However, it is not known whether imatinib affects future potential for fertility. Here we analysed ovaries and testes from adult mice receiving imatinib, focusing on testicular and ovarian functions. Seven male and 7 female mice were orally treated with 150 mg/kg body weight/day imatinib for two months. No effects on folliculogenesis or spermatogenesis could be observed postmortem by histological examinations, suggesting that, at least in two mouse models of imatinib treatment this tyrosine kinase inhibitor does not reduce fertility.Entities:
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Year: 2011 PMID： 22018447 DOI： 10.1016/j.leukres.2011.09.025
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156