Literature DB >> 22017865

Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.

Jun Yoshino1, Shin-ichiro Imai.   

Abstract

In this issue of Molecular Cell, Hirschey et al. demonstrate that loss of the NAD(+)-dependent deacetylase SIRT3 and resultant mitochondrial protein hyperacetylation play a critical role in the pathogenesis of metabolic syndrome, providing new insights into the therapeutic potential of SIRT3.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 22017865      PMCID： PMC3215590          DOI： 10.1016/j.molcel.2011.10.005

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.

Authors:  Shinichi Someya; Wei Yu; William C Hallows; Jinze Xu; James M Vann; Christiaan Leeuwenburgh; Masaru Tanokura; John M Denu; Tomas A Prolla
Journal:  Cell       Date:  2010-11-24       Impact factor: 41.582

2.  SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

Authors:  Matthew D Hirschey; Tadahiro Shimazu; Enxuan Jing; Carrie A Grueter; Amy M Collins; Bradley Aouizerat; Alena Stančáková; Eric Goetzman; Maggie M Lam; Bjoern Schwer; Robert D Stevens; Michael J Muehlbauer; Sanjay Kakar; Nathan M Bass; Johanna Kuusisto; Markku Laakso; Frederick W Alt; Christopher B Newgard; Robert V Farese; C Ronald Kahn; Eric Verdin
Journal:  Mol Cell       Date:  2011-10-21       Impact factor: 17.970

3.  Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Authors:  Jun Yoshino; Kathryn F Mills; Myeong Jin Yoon; Shin-ichiro Imai
Journal:  Cell Metab       Date:  2011-10-05       Impact factor: 27.287

Review 4.  Regulation of insulin secretion: role of mitochondrial signalling.

Authors:  S Jitrapakdee; A Wutthisathapornchai; J C Wallace; M J MacDonald
Journal:  Diabetologia       Date:  2010-03-12       Impact factor: 10.122

Review 5.  Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.

Authors:  Shin-ichiro Imai; Leonard Guarente
Journal:  Trends Pharmacol Sci       Date:  2010-03-11       Impact factor: 14.819

6.  Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.

Authors:  Enxuan Jing; Brice Emanuelli; Matthew D Hirschey; Jeremie Boucher; Kevin Y Lee; David Lombard; Eric M Verdin; C Ronald Kahn
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-22       Impact factor: 11.205

Review 7.  Regulation of intermediary metabolism by protein acetylation.

Authors:  Kun-Liang Guan; Yue Xiong
Journal:  Trends Biochem Sci       Date:  2010-10-08       Impact factor: 13.807

8.  SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

Authors:  Matthew D Hirschey; Tadahiro Shimazu; Eric Goetzman; Enxuan Jing; Bjoern Schwer; David B Lombard; Carrie A Grueter; Charles Harris; Sudha Biddinger; Olga R Ilkayeva; Robert D Stevens; Yu Li; Asish K Saha; Neil B Ruderman; James R Bain; Christopher B Newgard; Robert V Farese; Frederick W Alt; C Ronald Kahn; Eric Verdin
Journal:  Nature       Date:  2010-03-04       Impact factor: 49.962

9.  SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Authors:  Takashi Nakagawa; David J Lomb; Marcia C Haigis; Leonard Guarente
Journal:  Cell       Date:  2009-05-01       Impact factor: 41.582

10.  Endurance exercise as a countermeasure for aging.

Authors:  Ian R Lanza; Daniel K Short; Kevin R Short; Sreekumar Raghavakaimal; Rita Basu; Michael J Joyner; Joseph P McConnell; K Sreekumaran Nair
Journal:  Diabetes       Date:  2008-08-20       Impact factor: 9.461
  10 in total
  7 in total

1.  PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β.

Authors:  Xuefei Zhang; Xiaoqing Ren; Qi Zhang; Zheyi Li; Shuaipeng Ma; Jintao Bao; Zeyang Li; Xue Bai; Liangjun Zheng; Zhong Zhang; Shujiang Shang; Chen Zhang; Chuangui Wang; Liu Cao; Qingsong Wang; Jianguo Ji
Journal:  Antioxid Redox Signal       Date:  2015-11-19       Impact factor: 8.401

2.  Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress.

Authors:  Han Shi; Han-Xiang Deng; David Gius; Paul T Schumacker; D James Surmeier; Yong-Chao Ma
Journal:  Hum Mol Genet       Date:  2017-05-15       Impact factor: 6.150

Review 3.  Enzymatic and nonenzymatic protein acetylations control glycolysis process in liver diseases.

Authors:  Juan Li; Tongxin Wang; Jun Xia; Weilei Yao; Feiruo Huang
Journal:  FASEB J       Date:  2019-08-01       Impact factor: 5.191

4.  Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells.

Authors:  X Zhou; M Chen; X Zeng; J Yang; H Deng; L Yi; M T Mi
Journal:  Cell Death Dis       Date:  2014-12-18       Impact factor: 8.469

5.  The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.

Authors:  Xiaozhe Fu; Kejin Li; Yinjie Niu; Qiang Lin; Hongru Liang; Xia Luo; Lihui Liu; Ningqiu Li
Journal:  Microbiol Spectr       Date:  2022-01-12

Review 6.  Nutrigenomics and Nutrigenetics in Metabolic- (Dysfunction) Associated Fatty Liver Disease: Novel Insights and Future Perspectives.

Authors:  Marcello Dallio; Mario Romeo; Antonietta Gerarda Gravina; Mario Masarone; Tiziana Larussa; Ludovico Abenavoli; Marcello Persico; Carmelina Loguercio; Alessandro Federico
Journal:  Nutrients       Date:  2021-05-15       Impact factor: 5.717

Review 7.  NAD+ metabolism, stemness, the immune response, and cancer.

Authors:  Lola E Navas; Amancio Carnero
Journal:  Signal Transduct Target Ther       Date:  2021-01-01
  7 in total

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