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Literature DB >> 22016832

Base excision repair targets for cancer therapy.

Abstract

Cellular DNA repair is a frontline system that is responsible for maintaining genome integrity and thus preventing premature aging and cancer by repairing DNA lesions and strand breaks caused by endogenous and exogenous mutagens. However, it is also the principal cellular system in cancer cells that counteracts the killing effect of the major cancer treatments e.g. chemotherapy and ionizing radiation. The major goal of this review is to critically exam the base excision repair pathway and mechanisms regulating base excision repair capacity as a potential targets for improving cancer therapy.

Entities: Chemical

Keywords: DNA repair; base excision; cancer therapy; chemotherapy; ionizing radiation

Year: 2011 PMID： 22016832 PMCID： PMC3196283

Source DB: PubMed Journal: Am J Cancer Res ISSN： 2156-6976 Impact factor: 6.166

58 in total

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Authors: D P Lane
Journal: Nature Date: 1992-07-02 Impact factor: 49.962

2. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.

Authors: M R Kelley; L Cheng; R Foster; R Tritt; J Jiang; J Broshears; M Koch
Journal: Clin Cancer Res Date: 2001-04 Impact factor: 12.531

3. Two pathways for base excision repair in mammalian cells.

Authors: G Frosina; P Fortini; O Rossi; F Carrozzino; G Raspaglio; L S Cox; D P Lane; A Abbondandolo; E Dogliotti
Journal: J Biol Chem Date: 1996-04-19 Impact factor: 5.157

4. Requirement of mammalian DNA polymerase-beta in base-excision repair.

Authors: R W Sobol; J K Horton; R Kühn; H Gu; R K Singhal; R Prasad; K Rajewsky; S H Wilson
Journal: Nature Date: 1996-01-11 Impact factor: 49.962

5. DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.

Authors: Casey Lee; Brian A Smith; Keya Bandyopadhyay; Ruth A Gjerset
Journal: Cancer Res Date: 2005-11-01 Impact factor: 12.701

6. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers.

Authors: D H Moore; H Michael; R Tritt; S H Parsons; M R Kelley
Journal: Clin Cancer Res Date: 2000-02 Impact factor: 12.531

7. DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.

Authors: Jason L Parsons; Irina I Dianova; Sarah L Allinson; Grigory L Dianov
Journal: Biochemistry Date: 2005-08-09 Impact factor: 3.162

8. Role of poly(ADP-ribose) formation in DNA repair.

Authors: M S Satoh; T Lindahl
Journal: Nature Date: 1992-03-26 Impact factor: 49.962

9. A DNA polymerase beta mutant from colon cancer cells induces mutations.

Authors: Tieming Lang; Mausumi Maitra; Daniela Starcevic; Shu-Xia Li; Joann B Sweasy
Journal: Proc Natl Acad Sci U S A Date: 2004-04-09 Impact factor: 11.205

10. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair.

Authors: Y Matsumoto; K Kim
Journal: Science Date: 1995-08-04 Impact factor: 47.728

8 in total

Review 1. Unboxing the molecular modalities of mutagens in cancer.

Authors: Smita Kumari; Sudhanshu Sharma; Dia Advani; Akanksha Khosla; Pravir Kumar; Rashmi K Ambasta
Journal: Environ Sci Pollut Res Int Date: 2021-10-05 Impact factor: 5.190

2. Association of PARP1 polymorphisms with response to chemotherapy in patients with high-risk neuroblastoma.

Authors: Marianna Avitabile; Vito Alessandro Lasorsa; Sueva Cantalupo; Antonella Cardinale; Flora Cimmino; Annalaura Montella; Dalila Capasso; Riccardo Haupt; Loredana Amoroso; Alberto Garaventa; Alessandro Quattrone; Maria Valeria Corrias; Achille Iolascon; Mario Capasso
Journal: J Cell Mol Med Date: 2020-02-27 Impact factor: 5.310

Base excision repair targets for cancer therapy.

1. Cancer. p53, guardian of the genome.

2. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.

3. Two pathways for base excision repair in mammalian cells.

4. Requirement of mammalian DNA polymerase-beta in base-excision repair.

5. DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.

6. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers.

7. DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.

8. Role of poly(ADP-ribose) formation in DNA repair.

9. A DNA polymerase beta mutant from colon cancer cells induces mutations.

10. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair.

Review 1. Unboxing the molecular modalities of mutagens in cancer.

2. Association of PARP1 polymorphisms with response to chemotherapy in patients with high-risk neuroblastoma.

Review 3. Evolving insights: how DNA repair pathways impact cancer evolution.

4. PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations.

5. Role of p97/VCP (Cdc48) in genome stability.

Review 6. Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells.

7. IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.

8. Versatile cell-based assay for measuring DNA alkylation damage and its repair.