Literature DB >> 22016824

Circulating tumor cells: finding the needle in the haystack.

Xiaoning Zhe, Michael L Cher, R Daniel Bonfil.   

Abstract

Localized and metastatic cancers give rise to circulating tumor cells (CTCs) which are detectable in the bloodstream. Recent studies have highlighted the prognostic significance of the presence and number of CTCs, particularly in patients with metastatic disease. Future studies are designed not only to detect CTCs, but also to characterize them. This review discusses current and developing methodologies for the isolation and characterization of CTCs as well as recent studies focusing on the clinical relevance of CTC detection and characterization.

Entities:  

Keywords:  CTCs; Circulating tumor cells; cell capture and enumeration; detection technique; enrichment technique; immunomagnetic separation

Year:  2011        PMID： 22016824      PMCID： PMC3195935     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  67 in total

1.  Evaluation of multiparameter flow cytometry for the detection of breast cancer tumor cells in blood samples.

Authors:  Ignacio Cruz; Juana Ciudad; Juan Jesús Cruz; Manuel Ramos; Alberto Gómez-Alonso; Juan Carlos Adansa; Cesar Rodríguez; Alberto Orfao
Journal:  Am J Clin Pathol       Date:  2005-01       Impact factor: 2.493

2.  Characterization of metastatic breast cancer patients with nondetectable circulating tumor cells.

Authors:  Michal Mego; Ugo De Giorgi; Shahenaah Dawood; Xuemei Wang; Vicente Valero; Eleni Andreopoulou; Beverly Handy; Naoto T Ueno; James M Reuben; Massimo Cristofanilli
Journal:  Int J Cancer       Date:  2010-11-28       Impact factor: 7.396

3.  Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR.

Authors:  N Berois; M Varangot; B Aizen; R Estrugo; L Zarantonelli; P Fernández; G Krygier; F Simonet; E Barrios; I Musé; E Osinaga
Journal:  Eur J Cancer       Date:  2000-04       Impact factor: 9.162

4.  Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients.

Authors:  Catherine Alix-Panabières; Jean-Paul Brouillet; Michel Fabbro; Hans Yssel; Thérèse Rousset; Thierry Maudelonde; Genevieve Choquet-Kastylevsky; Jean-Pierre Vendrell
Journal:  J Immunol Methods       Date:  2005-04-12       Impact factor: 2.303

5.  Detection and quantification of small numbers of circulating tumour cells in peripheral blood using laser scanning cytometer (LSC).

Authors:  K Pachmann; P Heiss; U Demel; G Tilz
Journal:  Clin Chem Lab Med       Date:  2001-09       Impact factor: 3.694

6.  Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer.

Authors:  Steven J Cohen; Cornelis J A Punt; Nicholas Iannotti; Bruce H Saidman; Kert D Sabbath; Nashat Y Gabrail; Joel Picus; Michael Morse; Edith Mitchell; M Craig Miller; Gerald V Doyle; Henk Tissing; Leon W M M Terstappen; Neal J Meropol
Journal:  J Clin Oncol       Date:  2008-07-01       Impact factor: 44.544

7.  Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer.

Authors:  Nikolaos Xenidis; Michail Ignatiadis; Stella Apostolaki; Maria Perraki; Kostas Kalbakis; Sofia Agelaki; Efstathios N Stathopoulos; Grigorios Chlouverakis; Evi Lianidou; Stylianos Kakolyris; Vassilis Georgoulias; Dimitris Mavroudis
Journal:  J Clin Oncol       Date:  2009-03-30       Impact factor: 44.544

8.  Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor.

Authors:  André A Adams; Paul I Okagbare; Juan Feng; Matuesz L Hupert; Don Patterson; Jost Göttert; Robin L McCarley; Dimitris Nikitopoulos; Michael C Murphy; Steven A Soper
Journal:  J Am Chem Soc       Date:  2008-06-17       Impact factor: 15.419

9.  Detection of circulating epithelial cells in the blood of patients with breast cancer: comparison of three techniques.

Authors:  A E Ring; L Zabaglo; M G Ormerod; I E Smith; M Dowsett
Journal:  Br J Cancer       Date:  2005-03-14       Impact factor: 7.640

10.  Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer.

Authors:  Johann S de Bono; Howard I Scher; R Bruce Montgomery; Christopher Parker; M Craig Miller; Henk Tissing; Gerald V Doyle; Leon W W M Terstappen; Kenneth J Pienta; Derek Raghavan
Journal:  Clin Cancer Res       Date:  2008-10-01       Impact factor: 12.531
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  41 in total

1.  ApoStream(™), a new dielectrophoretic device for antibody independent isolation and recovery of viable cancer cells from blood.

Authors:  Vishal Gupta; Insiya Jafferji; Miguel Garza; Vladislava O Melnikova; David K Hasegawa; Ronald Pethig; Darren W Davis
Journal:  Biomicrofluidics       Date:  2012-06-27       Impact factor: 2.800

Review 2.  Circulating tumor cells: a review of present methods and the need to identify heterogeneous phenotypes.

Authors:  Lori M Millner; Mark W Linder; Roland Valdes
Journal:  Ann Clin Lab Sci       Date:  2013       Impact factor: 1.256

Review 3.  Cellular and molecular aspects of pancreatic cancer.

Authors:  A Gharibi; Y Adamian; J A Kelber
Journal:  Acta Histochem       Date:  2016-02-08       Impact factor: 2.479

4.  In vivo quantitation of injected circulating tumor cells from great saphenous vein based on video-rate confocal microscopy.

Authors:  Howon Seo; Yoonha Hwang; Kibaek Choe; Pilhan Kim
Journal:  Biomed Opt Express       Date:  2015-05-19       Impact factor: 3.732

Review 5.  Recent advances in microfluidic methods in cancer liquid biopsy.

Authors:  Florina S Iliescu; Daniel P Poenar; Fang Yu; Ming Ni; Kiat Hwa Chan; Irina Cima; Hayden K Taylor; Igor Cima; Ciprian Iliescu
Journal:  Biomicrofluidics       Date:  2019-07-23       Impact factor: 2.800

Review 6.  Circulating tumor cell isolation, culture, and downstream molecular analysis.

Authors:  Sandhya Sharma; Rachel Zhuang; Marisa Long; Mirjana Pavlovic; Yunqing Kang; Azhar Ilyas; Waseem Asghar
Journal:  Biotechnol Adv       Date:  2018-03-17       Impact factor: 14.227

7.  Multivalent Binding and Biomimetic Cell Rolling Improves the Sensitivity and Specificity of Circulating Tumor Cell Capture.

Authors:  Ja Hye Myung; Michael J Eblan; Joseph M Caster; Sin-Jung Park; Michael J Poellmann; Kyle Wang; Kevin A Tam; Seth M Miller; Colette Shen; Ronald C Chen; Tian Zhang; Joel E Tepper; Bhishamjit S Chera; Andrew Z Wang; Seungpyo Hong
Journal:  Clin Cancer Res       Date:  2018-03-15       Impact factor: 12.531

Review 8.  Nanotheranostics of circulating tumor cells, infections and other pathological features in vivo.

Authors:  Jin-Woo Kim; Ekaterina I Galanzha; David A Zaharoff; Robert J Griffin; Vladimir P Zharov
Journal:  Mol Pharm       Date:  2013-02-25       Impact factor: 4.939

Review 9.  Circulating tumor cells isolation: the "post-EpCAM era".

Authors:  Cristina Raimondi; Chiara Nicolazzo; Angela Gradilone
Journal:  Chin J Cancer Res       Date:  2015-10       Impact factor: 5.087

10.  Towards Engineered Processes for Sequencing-Based Analysis of Single Circulating Tumor Cells.

Authors:  Viktor A Adalsteinsson; J Christopher Love
Journal:  Curr Opin Chem Eng       Date:  2014-05-01       Impact factor: 5.163
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