BACKGROUND: Previous research showed acute diffusion-weighted imaging changes in pulvinar after extensive cortical injury from neonatal stroke. The authors used diffusion tensor imaging (DTI) to see how separate regions of ipsilateral thalamus are directly affected after a primary hit to their connected cortex in neonatal stroke. METHODS: The authors analysed DTI images of three term infants with acute unilateral cortical arterial ischaemic stroke. Probabilistic tractography was used to define separate thalamic regions of interests (ROIs). The authors evaluated the three eigenvalues (EV) and apparent diffusion coefficient (ADC) values in the ROIs. RESULTS: The ADC and EV in voxels of ROIs placed within the nuclei corresponding to ischaemic cortex were significantly lower than those in the unaffected contralesional thalamic nuclei. CONCLUSIONS: Our findings support the concept of acute network injury in neonatal stroke. ADC and EV were altered in specific thalamic regions that corresponded to the specific cortical areas affected by the primary ischaemic injury.
BACKGROUND: Previous research showed acute diffusion-weighted imaging changes in pulvinar after extensive cortical injury from neonatal stroke. The authors used diffusion tensor imaging (DTI) to see how separate regions of ipsilateral thalamus are directly affected after a primary hit to their connected cortex in neonatal stroke. METHODS: The authors analysed DTI images of three term infants with acute unilateral cortical arterial ischaemic stroke. Probabilistic tractography was used to define separate thalamic regions of interests (ROIs). The authors evaluated the three eigenvalues (EV) and apparent diffusion coefficient (ADC) values in the ROIs. RESULTS: The ADC and EV in voxels of ROIs placed within the nuclei corresponding to ischaemic cortex were significantly lower than those in the unaffected contralesional thalamic nuclei. CONCLUSIONS: Our findings support the concept of acute network injury in neonatal stroke. ADC and EV were altered in specific thalamic regions that corresponded to the specific cortical areas affected by the primary ischaemic injury.
Authors: Béatrice Skiöld; Qizhu Wu; Stuart B Hooper; Peter G Davis; Richard McIntyre; Mary Tolcos; James Pearson; Ruth Vreys; Gary F Egan; Samantha K Barton; Jeanie L Y Cheong; Graeme R Polglase Journal: PLoS One Date: 2014-04-23 Impact factor: 3.240
Authors: Lajos R Kozák; Szabolcs Dávid; Gábor Rudas; Zoltán Vidnyánszky; Alexander Leemans; Zoltán Nagy Journal: Neuroimage Date: 2012-12-14 Impact factor: 6.556
Authors: Lin Shi; Defeng Wang; Winnie C W Chu; Shangping Liu; Yunyun Xiong; Yilong Wang; Yongjun Wang; Lawrence K S Wong; Vincent C T Mok Journal: PLoS One Date: 2013-12-13 Impact factor: 3.240