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Literature DB >> 22015168

Synthesis of a Forssman antigen derivative for use in a conjugate vaccine.

Jianhao Feng¹, Rachel Hevey, Chang-Chun Ling.

Abstract

The total chemical synthesis of a Forssman antigen analog is described. The pentasaccharide contains a functionalized tether which should facilitate future conjugation with immunogenic proteins. We found that the total synthesis can be efficiently achieved by following a convergent 2+3 strategy, and using N-Troc protected GalNAc thioglycoside as a donor.

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Year: 2011 PMID： 22015168 DOI： 10.1016/j.carres.2011.09.015

Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104

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Cited

2 in total

1. Prevalence of antibodies to a new histo-blood system: the FORS system.

Authors: Carlos Jesus; Camilla Hesse; Clara Rocha; Nádia Osório; Ana Valado; Armando Caseiro; António Gabriel; Lola Svensson; Ali-Reza Moslemi; Wafa Abu Siba; Mahmoud A Srour; Cristina Pereira; Jorge Tomaz; Paulo Teixeira; Fernando Mendes
Journal: Blood Transfus Date: 2016-10-24 Impact factor: 3.443

2. Synthesis of α-D-GalpN₃-(1-3)-D-GalpN₃: α- and 3-O-selectivity using 3,4-diol acceptors.

Authors: Emil Glibstrup; Christian Marcus Pedersen
Journal: Beilstein J Org Chem Date: 2018-11-08 Impact factor: 2.883

2 in total

Synthesis of a Forssman antigen derivative for use in a conjugate vaccine.

1. Prevalence of antibodies to a new histo-blood system: the FORS system.

2. Synthesis of α-D-GalpN3-(1-3)-D-GalpN3: α- and 3-O-selectivity using 3,4-diol acceptors.

2. Synthesis of α-D-GalpN₃-(1-3)-D-GalpN₃: α- and 3-O-selectivity using 3,4-diol acceptors.