Literature DB >> 22014979

JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation.

Hyeonjung Kim1, Oisun Jung, Minkyung Kang, Mi-Sook Lee, Doyoung Jeong, Jihye Ryu, Youra Ko, Yoon-Ju Choi, Jung Weon Lee.   

Abstract

Transmembrane 4L six family member 5 (TM4SF5) can regulate cell-cell adhesion and cellular morphology via cytoplasmic p27(Kip1)-mediated changes in RhoA activity. However, how TM4SF5 causes cytosolic p27(Kip1) stabilization remains unknown. In this study we found that TM4SF5-mediated Ser10 phosphorylation of p27(Kip1) required for cytosolic localization was not always correlated with Akt activity. Inhibition or suppression of c-Jun N-terminal kinase (JNK) in TM4SF5-expressing cells decreased Ser10 phosphorylation of p27(Kip1) and rescued expression levels and localization of adherence junction molecules to cell-cell contacts. These observations suggest involvement of JNKs in TM4SF5-mediated p27(Kip1) Ser10 phosphorylation and localization during epithelial-mesenchymal transition.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 22014979     DOI： 10.1016/j.canlet.2011.09.030

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

Review 1.  JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships.

Authors:  András Zeke; Mariya Misheva; Attila Reményi; Marie A Bogoyevitch
Journal:  Microbiol Mol Biol Rev       Date:  2016-07-27       Impact factor: 11.056

2.  Clinicopathological significance of TM4SF5 expression in human hepatocellular carcinoma tissues.

Authors:  Baojin Xu; Wu Lv; Xiaoyan Li; Lina Zhang; Jie Lin
Journal:  Oncol Lett       Date:  2019-04-03       Impact factor: 2.967

3.  JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons.

Authors:  Abigail K Myers; Jessica G Cunningham; Skye E Smith; John P Snow; Catherine A Smoot; Eric S Tucker
Journal:  Development       Date:  2020-01-17       Impact factor: 6.868

4.  Prevention and therapy of hepatocellular carcinoma by vaccination with TM4SF5 epitope-CpG-DNA-liposome complex without carriers.

Authors:  Sanghoon Kwon; Dongbum Kim; Byoung Kwon Park; Sunhee Cho; Kwang Dong Kim; Young-Eun Kim; Cheung-Seog Park; Hyun-Jong Ahn; Jae-Nam Seo; Kyung-Chan Choi; Doo-Sik Kim; Younghee Lee; Hyung-Joo Kwon
Journal:  PLoS One       Date:  2012-03-12       Impact factor: 3.240

5.  TM4SF5 promotes metastatic behavior of cells in 3D extracellular matrix gels by reducing dependency on environmental cues.

Authors:  Dae-Geun Song; Gyu-Ho Lee; Seo Hee Nam; Jin-Gyu Cheong; Doyoung Jeong; Seo-Jin Lee; Cheol-Ho Pan; Jae Woo Jung; Hye-Jin Kim; Jihye Ryu; Ji Eon Kim; Somi Kim; Chang Yun Cho; Min-Kyung Kang; Kyung-Min Lee; Jung Weon Lee
Journal:  Oncotarget       Date:  2017-05-07

6.  Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity.

Authors:  Hye-Mi Ahn; Jihye Ryu; Jin Myeong Song; Yunhee Lee; Hye-Jin Kim; Dongjoon Ko; Inpyo Choi; Sang Jick Kim; Jung Weon Lee; Semi Kim
Journal:  Theranostics       Date:  2017-01-11       Impact factor: 11.556

7.  Partial hepatectomy in rats results in immediate down-regulation of p27Kip1 in residual liver tissue by transcriptional and post-translational processes.

Authors:  Anne-Katrin Rohlfing; Karoline Trescher; Juliane Hähnel; Christian Müller; Jan-Peter Hildebrandt
Journal:  Front Physiol       Date:  2013-06-13       Impact factor: 4.566

8.  TM4SF1 Promotes Gemcitabine Resistance of Pancreatic Cancer In Vitro and In Vivo.

Authors:  Jia Cao; Jiachun Yang; Vijaya Ramachandran; Thiruvengadam Arumugam; Defeng Deng; Zhaoshen Li; Leiming Xu; Craig D Logsdon
Journal:  PLoS One       Date:  2015-12-28       Impact factor: 3.240

Review 9.  Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5.

Authors:  Semi Kim; Jung Weon Lee
Journal:  Genomics Inform       Date:  2014-03-31

10.  JNK Signaling Regulates Cellular Mechanics of Cortical Interneuron Migration.

Authors:  Skye E Smith; Nicholas K Coker; Eric S Tucker
Journal:  eNeuro       Date:  2020-08-20
  10 in total

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