OBJECTIVE: To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation, pain and fever using animal models to support its actions. METHODS: Acute toxicity study of EENKC was performed in mice to fix the effective dose. The antipyretic, anti-inflammatory and analgesic activity of EENKC was evaluated in brewer's yeast induced pyrexia in rats, carrageenan-induced inflammation in rats and acetic-acid induced writhing in mice model. RESULTS: Acute toxicity revealed that EENKC didn't show death and toxic signs up to 2 000 mg/kg. In brewer's yeast induced pyrexia and carrageenan-induced inflammation EENKC at the doses of 200 and 400 mg/kg inhibited fever and inflammation significantly (P<0.01 and <0.05) compared to control animals. In mice, the number of writhing induced by acetic-acid was significantly (P<0.01) reduced after treatment with both the dose of EENKC than control animals. EENKC 200 mg/kg inhibits inflammation higher level in carrageenan-induced paw edema, but there is no significant difference when compared to indomethacin 10 mg/kg. CONCLUSIONS: The present findings revealed that EENKC possesses antipyretic, anti-inflammatory and analgesic activity which supports nilavembu kudineer choornam efficacy in chikungunya fever.
OBJECTIVE: To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation, pain and fever using animal models to support its actions. METHODS: Acute toxicity study of EENKC was performed in mice to fix the effective dose. The antipyretic, anti-inflammatory and analgesic activity of EENKC was evaluated in brewer's yeast induced pyrexia in rats, carrageenan-induced inflammation in rats and acetic-acid induced writhing in mice model. RESULTS: Acute toxicity revealed that EENKC didn't show death and toxic signs up to 2 000 mg/kg. In brewer's yeast induced pyrexia and carrageenan-induced inflammationEENKC at the doses of 200 and 400 mg/kg inhibited fever and inflammation significantly (P<0.01 and <0.05) compared to control animals. In mice, the number of writhing induced by acetic-acid was significantly (P<0.01) reduced after treatment with both the dose of EENKC than control animals. EENKC 200 mg/kg inhibits inflammation higher level in carrageenan-induced paw edema, but there is no significant difference when compared to indomethacin 10 mg/kg. CONCLUSIONS: The present findings revealed that EENKC possesses antipyretic, anti-inflammatory and analgesic activity which supports nilavembu kudineer choornam efficacy in chikungunya fever.