OBJECTIVE: The purpose of this study was to examine a range of cognitive measures as candidate phenotypic liability markers for psychosis in a uniquely large sample of patients with psychosis, their unaffected relatives and control subjects. METHOD: Patients with non-affective psychosis (n = 1093), their unaffected siblings (n = 1044), parents (n = 911), and controls (n = 587) completed a comprehensive cognitive test battery. Cognitive functioning was compared using tests of verbal learning and memory, attention/vigilance, working memory, processing speed, reasoning and problem solving, acquired knowledge, and social cognition. Age- and gender-adjusted z-scores were compared between groups using mixed-model analyses of covariance. Clinically relevant impairment (-1 and -2 SD from control mean) was compared between subject groups. RESULTS: Patients performed significantly worse than controls in all cognitive domains (z-range -0.26 to -1.34). Siblings and parents showed alterations for immediate verbal learning, processing speed, reasoning and problem solving, acquired knowledge, and working memory (z-range -0.22 to -0.98). Parents showed additional alterations for social cognition. Prevalence of clinically relevant impairment in relatives ranged from 50% (-1 SD criterion) to 10% (-2 SD criterion). CONCLUSION: Cognitive functioning is a candidate intermediate phenotype given significant small to large alterations in patients and intermediate alterations in first-degree relatives.
OBJECTIVE: The purpose of this study was to examine a range of cognitive measures as candidate phenotypic liability markers for psychosis in a uniquely large sample of patients with psychosis, their unaffected relatives and control subjects. METHOD:Patients with non-affective psychosis (n = 1093), their unaffected siblings (n = 1044), parents (n = 911), and controls (n = 587) completed a comprehensive cognitive test battery. Cognitive functioning was compared using tests of verbal learning and memory, attention/vigilance, working memory, processing speed, reasoning and problem solving, acquired knowledge, and social cognition. Age- and gender-adjusted z-scores were compared between groups using mixed-model analyses of covariance. Clinically relevant impairment (-1 and -2 SD from control mean) was compared between subject groups. RESULTS:Patients performed significantly worse than controls in all cognitive domains (z-range -0.26 to -1.34). Siblings and parents showed alterations for immediate verbal learning, processing speed, reasoning and problem solving, acquired knowledge, and working memory (z-range -0.22 to -0.98). Parents showed additional alterations for social cognition. Prevalence of clinically relevant impairment in relatives ranged from 50% (-1 SD criterion) to 10% (-2 SD criterion). CONCLUSION: Cognitive functioning is a candidate intermediate phenotype given significant small to large alterations in patients and intermediate alterations in first-degree relatives.
Authors: Bernice C van Aken; Ayuk Bakia; André I Wierdsma; Yolande Voskes; Jaap Van Weeghel; Evelyn M M van Bussel; Carla Hagestein; Andrea M Ruissen; Pien Leendertse; Wishal V Sewbalak; Daphne A van der Draai; Alice Hammink; M E Mandos; Mark van der Gaag; Annette E Bonebakker; Christina M Van Der Feltz-Cornelis; Cornelis L Mulder Journal: Front Psychiatry Date: 2021-01-12 Impact factor: 4.157
Authors: Ana González-Pinto; Itxaso González-Ortega; Susana Alberich; Sonia Ruiz de Azúa; Miguel Bernardo; Miquel Bioque; Bibiana Cabrera; Iluminada Corripio; Celso Arango; Antonio Lobo; Ana M Sánchez-Torres; Manuel J Cuesta Journal: PLoS One Date: 2016-08-11 Impact factor: 3.240
Authors: Md A Islam; T D Habtewold; F D van Es; P J Quee; E R van den Heuvel; B Z Alizadeh; R Bruggeman Journal: Acta Psychiatr Scand Date: 2018-09-21 Impact factor: 6.392
Authors: Giada Tripoli; Diego Quattrone; Laura Ferraro; Charlotte Gayer-Anderson; Caterina La Cascia; Daniele La Barbera; Crocettarachele Sartorio; Fabio Seminerio; Victoria Rodriguez; Ilaria Tarricone; Domenico Berardi; Stéphane Jamain; Celso Arango; Andrea Tortelli; Pierre-Michel Llorca; Lieuwe de Haan; Eva Velthorst; Julio Bobes; Miquel Bernardo; Julio Sanjuán; Jose Luis Santos; Manuel Arrojo; Cristina Marta Del-Ben; Paulo Rossi Menezes; Els van der Ven; Peter B Jones; Hannah E Jongsma; James B Kirkbride; Sarah Tosato; Antonio Lasalvia; Alex Richards; Michael O'Donovan; Bart P F Rutten; Jim van Os; Craig Morgan; Pak C Sham; Marta Di Forti; Robin M Murray; Graham K Murray Journal: Schizophr Bull Date: 2022-09-01 Impact factor: 7.348