Literature DB >> 22013194

Driving with no brakes: molecular pathophysiology of Kv7 potassium channels.

Maria Virginia Soldovieri1, Francesco Miceli, Maurizio Taglialatela.   

Abstract

Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here, we describe their molecular architecture, physiological roles, and involvement in genetically determined channelopathies highlighting their relevance as targets for pharmacological treatment of several human disorders.

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Year:  2011        PMID： 22013194     DOI： 10.1152/physiol.00009.2011

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  64 in total

1.  The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.

Authors:  Ruhma Syeda; Jose S Santos; Mauricio Montal
Journal:  J Biol Chem       Date:  2015-12-01       Impact factor: 5.157

2.  KV7 Channel Pharmacological Activation by the Novel Activator ML213: Role for Heteromeric KV7.4/KV7.5 Channels in Guinea Pig Detrusor Smooth Muscle Function.

Authors:  Aaron Provence; Damiano Angoli; Georgi V Petkov
Journal:  J Pharmacol Exp Ther       Date:  2017-10-30       Impact factor: 4.030

3.  Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.

Authors:  Haibo Yu; Zhihong Lin; Margrith E Mattmann; Beiyan Zou; Cecile Terrenoire; Hongkang Zhang; Meng Wu; Owen B McManus; Robert S Kass; Craig W Lindsley; Corey R Hopkins; Min Li
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-06       Impact factor: 11.205

4.  KCNQ2 Potassium Channel Epileptic Encephalopathy Syndrome: Divorce of an Electro-Mechanical Couple?

Authors:  John J Millichap; Edward C Cooper
Journal:  Epilepsy Curr       Date:  2012-07       Impact factor: 7.500

5.  Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370.

Authors:  T A Jepps; B H Bentzen; J B Stott; O V Povstyan; K Sivaloganathan; W Dalby-Brown; I A Greenwood
Journal:  Br J Pharmacol       Date:  2014-08-14       Impact factor: 8.739

6.  A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function.

Authors:  Aram Chang; Fayal Abderemane-Ali; Greg L Hura; Nathan D Rossen; Rachel E Gate; Daniel L Minor
Journal:  Neuron       Date:  2018-02-08       Impact factor: 17.173

7.  Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels.

Authors:  Joseph Lombardo; Melissa A Harrington
Journal:  J Neurophysiol       Date:  2016-08-10       Impact factor: 2.714

Review 8.  Modulation of Kv7 channels and excitability in the brain.

Authors:  Derek L Greene; Naoto Hoshi
Journal:  Cell Mol Life Sci       Date:  2016-09-19       Impact factor: 9.261

9.  Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.

Authors:  Shuang Li; Veronica Choi; Thanos Tzounopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-28       Impact factor: 11.205

Review 10.  One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.

Authors:  T A Jepps; S P Olesen; I A Greenwood
Journal:  Br J Pharmacol       Date:  2013-01       Impact factor: 8.739
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