Literature DB >> 2201313

An insulin-like compound consisting of the B-chain of bovine insulin and an A-chain corresponding to a modified A- and the D-domains of human insulin-like growth factor I.

S Joshi1, G T Burke, P G Katsoyannis.   

Abstract

We report the synthesis and biological evaluation of a two-chain, disulfide-linked, insulin-like compound consisting of the B-chain of bovine insulin and an A-chain corresponding to the A- and D- domains of human insulin-like growth factor-I (IGF-I) in which the A-domain amino-acid residues -Phe49-Arg50-Ser51-found in IGF-I have been replaced by -Ala-Gly-Val-, the homologous region of sheep insulin. The compound is indistinguishable from a previously reported compound whose A-chain corresponds to the A- and D-domains of IGF-I without the substitution, in assays for insulin-like activity as well as in assays for growth-promoting activity. We conclude that these A-domain residues do not contribute significantly to the interaction of IGF-I with either insulin or IGF-I receptors.

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Year:  1990        PMID： 2201313     DOI： 10.1007/bf01025314

Source DB:  PubMed          Journal:  J Protein Chem        ISSN： 0277-8033


  20 in total

1.  The renal clearance of thiosulfate with observations on its volume distribution.

Authors:  A GILMAN; F S PHILIPS; E S KOELLE
Journal:  Am J Physiol       Date:  1946-06

2.  Cellular binding sites for insulin in rat liver.

Authors:  A Horvat; E Li; P G Katsoyannis
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3.  Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method.

Authors:  D Yamashiro; C H Li
Journal:  J Am Chem Soc       Date:  1973-02-21       Impact factor: 15.419

4.  Synthesis of an insulin-like compound consisting of the A chain of insulin and a B chain corresponding to the B domain of human insulin-like growth factor I.

Authors:  S Joshi; G T Burke; P G Katsoyannis
Journal:  Biochemistry       Date:  1985-07-16       Impact factor: 3.162

5.  Species variation in the amino acid sequence of insulin.

Authors:  L F Smith
Journal:  Am J Med       Date:  1966-05       Impact factor: 4.965

6.  Studies on the synthesis of insulin from natural and synthetic A and B chains. I. Splitting of insulin and isolation of the S-sulfonated derivatives of the A and B chains.

Authors:  P G Katsoyannis; A Tometsko; C Zalut; S Johnson; A C Trakatellis
Journal:  Biochemistry       Date:  1967-09       Impact factor: 3.162

7.  Studies on the synthesis of insulin from natural and synthetic A and B chains. 3. Synthetic insulins.

Authors:  P G Katsoyannis; A C Trakatellis; C Zalut; S Johnson; A Tometsko; G Schwartz; J Ginos
Journal:  Biochemistry       Date:  1967-09       Impact factor: 3.162

8.  Hybrid molecules containing the B-domain of insulin-like growth factor I are recognized by carrier proteins of the growth factor.

Authors:  M A De Vroede; M M Rechler; S P Nissley; S Joshi; G T Burke; P G Katsoyannis
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

9.  Critical role of the A2 amino acid residue in the biological activity of insulin: [2-glycine-A]- and [2-alanine-A]insulins.

Authors:  K Kitagawa; H Ogawa; G T Burke; J D Chanley; P G Katsoyannis
Journal:  Biochemistry       Date:  1984-03-27       Impact factor: 3.162

10.  Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding.

Authors:  T L Blundell; S Bedarkar; E Rinderknecht; R E Humbel
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205
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  6 in total

1.  Contribution of the B16 and B26 tyrosine residues to the biological activity of insulin.

Authors:  S Q Hu; G T Burke; P G Katsoyannis
Journal:  J Protein Chem       Date:  1993-12

2.  An insulin-like hybrid consisting of a modified A-domain of human insulin-like growth factor I and the B-chain of insulin.

Authors:  L Zong; G T Burke; P G Katsoyannis
Journal:  J Protein Chem       Date:  1990-08

3.  The effect of placement of tryptophan residues in selected A-chain positions on the biological profile of insulin.

Authors:  Y C Chu; G T Burke; J B Ross; P G Katsoyannis
Journal:  J Protein Chem       Date:  1993-08

4.  Insulin analogues with modifications in the beta-turn of the B-chain.

Authors:  S H Wang; S Q Hu; G T Burke; P G Katsoyannis
Journal:  J Protein Chem       Date:  1991-06

5.  5-Hydroxytryptophan: an absorption and fluorescence probe which is a conservative replacement for [A14 tyrosine] in insulin.

Authors:  W R Laws; G P Schwartz; E Rusinova; G T Burke; Y C Chu; P G Katsoyannis; J B Ross
Journal:  J Protein Chem       Date:  1995-05

6.  The A14 position of insulin tolerates considerable structural alterations with modest effects on the biological behavior of the hormone.

Authors:  Y C Chu; L Zong; G T Burke; P G Katsoyannis
Journal:  J Protein Chem       Date:  1992-10
  6 in total

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