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Literature DB >> 22012849

The mechanism of the second step of pre-mRNA splicing.

Abstract

The molecular mechanisms of the second step of pre-mRNA splicing in yeast and higher eukaryotes are reviewed. The important elements in the pre-mRNA, the participating proteins, and the proposed secondary structures and roles of the snRNAs are described. The sequence of events in the second step is presented, focusing on the actions of the proteins in setting up and facilitating the second reaction. Mechanisms for avoiding errors in splicing are discussed.

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Year: 2011 PMID： 22012849 DOI： 10.1002/wrna.112

Source DB: PubMed Journal: Wiley Interdiscip Rev RNA ISSN： 1757-7004 Impact factor: 9.957

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Cited

20 in total

1. Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.

Authors: Thomas Ohrt; Mira Prior; Julia Dannenberg; Peter Odenwälder; Olexandr Dybkov; Nicolas Rasche; Jana Schmitzová; Ingo Gregor; Patrizia Fabrizio; Jörg Enderlein; Reinhard Lührmann
Journal: RNA Date: 2012-04-25 Impact factor: 4.942

2. Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

Authors: Karl Bertram; Dmitry E Agafonov; Wen-Ti Liu; Olexandr Dybkov; Cindy L Will; Klaus Hartmuth; Henning Urlaub; Berthold Kastner; Holger Stark; Reinhard Lührmann
Journal: Nature Date: 2017-01-11 Impact factor: 49.962

3. Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system.

Authors: Jean-Baptiste Fourmann; Jana Schmitzová; Henning Christian; Henning Urlaub; Ralf Ficner; Kum-Loong Boon; Patrizia Fabrizio; Reinhard Lührmann
Journal: Genes Dev Date: 2013-02-15 Impact factor: 11.361

4. The Fission Yeast Pre-mRNA-processing Factor 18 (prp18+) Has Intron-specific Splicing Functions with Links to G1-S Cell Cycle Progression.

Authors: Nagampalli Vijaykrishna; Geetha Melangath; Rakesh Kumar; Piyush Khandelia; Pushpinder Bawa; Raghavan Varadarajan; Usha Vijayraghavan
Journal: J Biol Chem Date: 2016-11-15 Impact factor: 5.157

The mechanism of the second step of pre-mRNA splicing.

1. Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.

2. Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

3. Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system.

4. The Fission Yeast Pre-mRNA-processing Factor 18 (prp18+) Has Intron-specific Splicing Functions with Links to G1-S Cell Cycle Progression.

5. Transient RNA structure features are evolutionarily conserved and can be computationally predicted.

6. Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.

7. Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex.

Review 8. On the importance of cotranscriptional RNA structure formation.

9. Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection.

10. Prevalent and distinct spliceosomal 3'-end processing mechanisms for fungal telomerase RNA.