BACKGROUND: Previous studies reported on post-radiation sarcomas. However, the incidence, latency from radiation therapy, treatment, and survival has been difficult to evaluate. We performed a retrospective, single-institutional study to determine these factors for post-radiation sarcomas. MATERIALS AND METHODS: We retrospectively studied 52 patients with post-radiation sarcomas diagnosed and treated from 1985 to 2011. The mean age was 49 years; 45 patients had bone and 7 soft tissue sarcoma. The mean follow-up was 45 months. Survival was analyzed with respect to age at diagnosis, type (bone vs. soft tissue), histology, location (trunk vs. extremities), size, and surgical treatment (resection vs. amputation). RESULTS: The risk of post-radiation sarcoma was 0.06% at a mean latency of 15 years (3-50 years) after radiation therapy. The most common histology was osteosarcoma followed by malignant fibrous histiocytoma and fibrosarcoma; all sarcomas were high grade. Survival of the patients with post-radiation sarcomas was 85% at 1 year, 51% at 2 years, 48% at 3 years, and 45% at 5 years. Univariate predictor of survival was only the type of the sarcoma. No variable was significant in multivariate analysis. CONCLUSIONS: Prognosis of post-radiation sarcomas is poor; the type of the sarcomas is the only significant variable for survival.
BACKGROUND: Previous studies reported on post-radiation sarcomas. However, the incidence, latency from radiation therapy, treatment, and survival has been difficult to evaluate. We performed a retrospective, single-institutional study to determine these factors for post-radiation sarcomas. MATERIALS AND METHODS: We retrospectively studied 52 patients with post-radiation sarcomas diagnosed and treated from 1985 to 2011. The mean age was 49 years; 45 patients had bone and 7 soft tissue sarcoma. The mean follow-up was 45 months. Survival was analyzed with respect to age at diagnosis, type (bone vs. soft tissue), histology, location (trunk vs. extremities), size, and surgical treatment (resection vs. amputation). RESULTS: The risk of post-radiation sarcoma was 0.06% at a mean latency of 15 years (3-50 years) after radiation therapy. The most common histology was osteosarcoma followed by malignant fibrous histiocytoma and fibrosarcoma; all sarcomas were high grade. Survival of the patients with post-radiation sarcomas was 85% at 1 year, 51% at 2 years, 48% at 3 years, and 45% at 5 years. Univariate predictor of survival was only the type of the sarcoma. No variable was significant in multivariate analysis. CONCLUSIONS: Prognosis of post-radiation sarcomas is poor; the type of the sarcomas is the only significant variable for survival.
Authors: Jennifer LaFemina; Li-Xuan Qin; Nicole H Moraco; Cristina R Antonescu; Ryan C Fields; Aimee M Crago; Murray F Brennan; Samuel Singer Journal: Ann Surg Oncol Date: 2012-08-10 Impact factor: 5.344
Authors: Sean P Dineen; Christina L Roland; Rachel Feig; Caitlin May; Shouhao Zhou; Elizabeth Demicco; Ghadah Al Sannaa; Davis Ingram; Wei-Lein Wang; Vinod Ravi; Ashleigh Guadagnolo; Dina Lev; Raphael E Pollock; Kelly Hunt; Janice Cormier; Alex Lazar; Barry Feig; Keila E Torres Journal: Ann Surg Oncol Date: 2015-03-06 Impact factor: 5.344
Authors: N G Burnet; P Nasr; G Yip; J E Scaife; T House; S J Thomas; F Harris; P J Owen; P Hull Journal: Br J Radiol Date: 2014-08-04 Impact factor: 3.039