Literature DB >> 22011731

Transannular Claisen rearrangement reactions for the synthesis of vinylcyclobutanes: formal synthesis of (±)-grandisol.

Donald Craig1, Kiyohiko Funai, Sophie J Gore, Albert Kang, Alexander V W Mayweg.   

Abstract

Unsaturated eight-membered lactones undergo decarboxylative and non-decarboxylative transannular Ireland-Claisen rearrangement reactions, to give substituted vinylcyclobutanes. A formal synthesis of (±)-grandisol is described.

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Year:  2011        PMID： 22011731     DOI： 10.1039/c1ob06619f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  1 in total

1.  Total Synthesis of (-)-Mitrephorone A Enabled by Stereoselective Nitrile Oxide Cycloaddition and Tetrasubstituted Olefin Synthesis.

Authors:  Michael Schneider; Matthieu J R Richter; Erick M Carreira
Journal:  J Am Chem Soc       Date:  2020-10-06       Impact factor: 15.419
  1 in total

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