Literature DB >> 22008773

Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan.

F Qazi1, U Khan, S Khowaja, M Javaid, A Ahmed, N Salahuddin, H Hussain, M C Becerra, J E Golub, A J Khan.   

Abstract

Culture conversion is an interim monitoring tool for treatment of multidrug-resistant tuberculosis (MDR-TB). We evaluated the time to and predictors of culture conversion in pulmonary MDR-TB patients enrolled in the community-based MDR-TB management program at the Indus Hospital in Karachi, Pakistan. Despite strict daily directly observed therapy, monthly food incentives and patient counseling, the median time to culture conversion was 196 days (range 32-471). The cumulative probabilities of culture conversion by 2, 4, 6 and 12 months were respectively 6%, 33%, 47%, and 73%. Smoking, high smear grade at baseline and previous use of second-line drugs delayed culture conversion.

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Year:  2011        PMID： 22008773      PMCID： PMC6203961          DOI： 10.5588/ijtld.10.0679

Source DB:  PubMed          Journal:  Int J Tuberc Lung Dis        ISSN： 1027-3719            Impact factor:   2.373


  7 in total

1.  Factors predicting persistent sputum smear positivity among pulmonary tuberculosis patients 2 months after treatment.

Authors:  R Singla; M M Osman; N Khan; N Al-Sharif; M O Al-Sayegh; M A Shaikh
Journal:  Int J Tuberc Lung Dis       Date:  2003-01       Impact factor: 2.373

2.  Speaking the same language: treatment outcome definitions for multidrug-resistant tuberculosis.

Authors:  K F Laserson; L E Thorpe; V Leimane; K Weyer; C D Mitnick; V Riekstina; E Zarovska; M L Rich; H S F Fraser; E Alarcón; J P Cegielski; M Grzemska; R Gupta; M Espinal
Journal:  Int J Tuberc Lung Dis       Date:  2005-06       Impact factor: 2.373

3.  Community-based treatment for multidrug-resistant tuberculosis in rural KwaZulu-Natal, South Africa.

Authors:  T Heller; R J Lessells; C G Wallrauch; T Bärnighausen; G S Cooke; L Mhlongo; I Master; M L Newell
Journal:  Int J Tuberc Lung Dis       Date:  2010-04       Impact factor: 2.373

4.  Association of conversion & cure with initial smear grading among new smear positive pulmonary tuberculosis patients treated with Category I regimen.

Authors:  P G Gopi; V Chandrasekaran; R Subramani; T Santha; A Thomas; N Selvakumar; P R Narayanan
Journal:  Indian J Med Res       Date:  2006-06       Impact factor: 2.375

5.  Time to sputum culture conversion in multidrug-resistant tuberculosis: predictors and relationship to treatment outcome.

Authors:  Timothy H Holtz; Maya Sternberg; Steve Kammerer; Kayla F Laserson; Vija Riekstina; Evija Zarovska; Vija Skripconoka; Charles D Wells; Vaira Leimane
Journal:  Ann Intern Med       Date:  2006-05-02       Impact factor: 25.391

6.  A randomised controlled trial of high-dose isoniazid adjuvant therapy for multidrug-resistant tuberculosis.

Authors:  S K Katiyar; S Bihari; S Prakash; M Mamtani; H Kulkarni
Journal:  Int J Tuberc Lung Dis       Date:  2008-02       Impact factor: 2.373

7.  Factors determining the outcome of treatment of adult smear-positive tuberculosis cases in The Gambia.

Authors:  C Lienhardt; K Manneh; V Bouchier; G Lahai; P J Milligan; K P McAdam
Journal:  Int J Tuberc Lung Dis       Date:  1998-09       Impact factor: 2.373
  7 in total
  24 in total

1.  Time for culture conversion and its associated factors in multidrug-resistant tuberculosis patients at a tertiary level hospital in Peshawar, Pakistan.

Authors:  Zafar Iqbal; Mazhar Ali Khan; Aamir Aziz; Syed Muhammad Nasir
Journal:  Pak J Med Sci       Date:  2022 Mar-Apr       Impact factor: 2.340

2.  Validity of Time to Sputum Culture Conversion to Predict Cure in Patients with Multidrug-Resistant Tuberculosis: A Retrospective Single-Center Study.

Authors:  Arshad Javaid; Nafees Ahmad; Afsar Khan Afridi; Anila Basit; Amer Hayat Khan; Izaz Ahmad; Muhammad Atif
Journal:  Am J Trop Med Hyg       Date:  2018-03-29       Impact factor: 2.345

3.  Good quality locally procured drugs can be as effective as internationally quality assured drugs in treating multi-drug resistant tuberculosis.

Authors:  Ejaz Qadeer; Razia Fatima; Katherine Fielding; Fahad Qazi; David Moore; Mishal S Khan
Journal:  PLoS One       Date:  2015-04-29       Impact factor: 3.240

4.  Time to culture conversion and regimen composition in multidrug-resistant tuberculosis treatment.

Authors:  Dylan B Tierney; Molly F Franke; Mercedes C Becerra; Félix A Alcántara Virú; César A Bonilla; Epifanio Sánchez; Dalia Guerra; Maribel Muñoz; Karim Llaro; Eda Palacios; Lorena Mestanza; Rocío M Hurtado; Jennifer J Furin; Sonya Shin; Carole D Mitnick
Journal:  PLoS One       Date:  2014-09-19       Impact factor: 3.240

5.  Development of multidrug resistant tuberculosis in Bangladesh: a case-control study on risk factors.

Authors:  Mahfuza Rifat; Abul Hasnat Milton; John Hall; Christopher Oldmeadow; Md Akramul Islam; Ashaque Husain; Md Wahiduzzaman Akhanda; Bodrun Naher Siddiquea
Journal:  PLoS One       Date:  2014-08-19       Impact factor: 3.240

6.  Effectiveness of a government-organized and hospital-initiated treatment for multidrug-resistant tuberculosis patients--a retrospective cohort study.

Authors:  Pei-Chun Chan; Su-Hua Huang; Ming-Chih Yu; Shih-Wei Lee; Yi-Wen Huang; Shun-Tien Chien; Jen-Jyh Lee
Journal:  PLoS One       Date:  2013-02-25       Impact factor: 3.240

7.  Predictors of two months culture conversion in multidrug-resistant tuberculosis: findings from a retrospective cohort study.

Authors:  Anila Basit; Nafees Ahmad; Amer Hayat Khan; Arshad Javaid; Syed Azhar Syed Sulaiman; Afsar Khan Afridi; Azreen Syazril Adnan; Israr ul Haq; Syed Saleem Shah; Ahmed Ahadi; Izaz Ahmad
Journal:  PLoS One       Date:  2014-04-04       Impact factor: 3.240

8.  Diabetes mellitus, smoking status, and rate of sputum culture conversion in patients with multidrug-resistant tuberculosis: a cohort study from the country of Georgia.

Authors:  Matthew J Magee; Russell R Kempker; Maia Kipiani; Nestani Tukvadze; Penelope P Howards; K M Venkat Narayan; Henry M Blumberg
Journal:  PLoS One       Date:  2014-04-15       Impact factor: 3.240

9.  Efficacy and effect of free treatment on multidrug-resistant tuberculosis.

Authors:  Qing Zhang; Zheyuan Wu; Zurong Zhang; Wei Sha; Xin Shen; Heping Xiao
Journal:  Exp Ther Med       Date:  2015-12-29       Impact factor: 2.447

10.  Clinical Features and Treatment Outcomes of Patients with Drug-Resistant and Drug-Sensitive Tuberculosis: A Historical Cohort Study in Porto Alegre, Brazil.

Authors:  Vania Celina Dezoti Micheletti; Afrânio Lineu Kritski; José Ueleres Braga
Journal:  PLoS One       Date:  2016-08-09       Impact factor: 3.240
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