Literature DB >> 22007723

Analgesic and anti-inflammatory activities of the sesquiterpene fraction from Annona reticulata L. bark.

Machindra J Chavan1, Pravin S Wakte, Devanand B Shinde.   

Abstract

The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components were identified: copaene (35.40%), patchoulane (13.49%) and 1H-cycloprop(e)azulene (22.77%). The fraction was also screened for its analgesic and anti-inflammatory activities. The sesquiterpene fraction at doses 12.5 and 25 mg kg⁻¹ and the unsaponified petroleum ether extract at a dose of 50 mg kg⁻¹ exhibited significant central as well as peripheral analgesic and anti-inflammatory activities. These activities were comparable with the standard drugs used in the respective experiments.

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Year:  2011        PMID： 22007723     DOI： 10.1080/14786419.2011.564583

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  10 in total

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  10 in total

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