Literature DB >> 2200708

Endothelin stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum-free medium.

T Suzuki1, H Hoshi, Y Mitsui.   

Abstract

The effect of endothelin (ET) on rat cardiac myocytes cultured in a serum-free, defined medium was determined. ET simulated cardiac myocyte hypertrophy in a dose-dependent manner as determined by the protein synthesis and cell surface area. Since the myocyte hypertrophy was abolished by H-7, a protein kinase C inhibitor, ET-receptor mediated protein kinase C activation may be involved in cardiac myocyte hypertrophy. At the same time, ET also stimulated myocyte contractility in this medium, and this stimulatory effect was inhibited by nicardipine. This result indicates that the influx of extracellular calcium ion is necessary for the stimulation of contractility induced by ET.

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Year:  1990        PMID： 2200708     DOI： 10.1016/0014-5793(90)80995-u

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Establishment of vascular endothelial cell lines in a serum-free culture and the discovery of endothelin and a Vasoactive Intestinal Contractor (VIC).

Authors:  Y Mitsui; K Saida; N Ishida; T Imamura; M Kobayashi
Journal:  Cytotechnology       Date:  1991-01       Impact factor: 2.058

2.  Midregional pro-atrial natriuretic peptide: a novel marker of myocardial fibrosis in patients with hypertrophic cardiomyopathy.

Authors:  Elif Elmas; Christina Doesch; Stephan Fluechter; Miriam Freundt; Christel Weiss; Siegfried Lang; Thorsten Kälsch; Dariush Haghi; Jana Papassotiriou; Jan Kunde; Stefan O Schoenberg; Martin Borggrefe; Theano Papavassiliu
Journal:  Int J Cardiovasc Imaging       Date:  2010-09-26       Impact factor: 2.357

Review 3.  Calcium antagonists and endothelial function: focus on nitric oxide and endothelin.

Authors:  T Godfraind; S Salomone
Journal:  Cardiovasc Drugs Ther       Date:  1996-09       Impact factor: 3.727

4.  Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy.

Authors:  Jessica Pfleger; Ryan C Coleman; Jessica Ibetti; Rajika Roy; Ioannis D Kyriazis; Erhe Gao; Konstantinos Drosatos; Walter J Koch
Journal:  Circulation       Date:  2020-07-09       Impact factor: 29.690

Review 5.  Endothelin: potential role in development and disease.

Authors:  V Kon; A Fogo
Journal:  Pediatr Nephrol       Date:  1993-12       Impact factor: 3.714

6.  Action of the calcium channel blocker lacidipine on cardiac hypertrophy and endothelin-1 gene expression in stroke-prone hypertensive rats.

Authors:  O Feron; S Salomone; T Godfraind
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

7.  FP-receptor mediated trophic effects of prostanoids in rat ventricular cardiomyocytes.

Authors:  K Pönicke; C Giessler; M Grapow; I Heinroth-Hoffmann; K Becker; B Osten; O E Brodde
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

Review 8.  Neurohormonal connections with mitochondria in cardiomyopathy and other diseases.

Authors:  Gerald W Dorn
Journal:  Am J Physiol Cell Physiol       Date:  2022-06-27       Impact factor: 5.282

9.  Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes.

Authors:  H Ito; Y Hirata; S Adachi; M Tanaka; M Tsujino; A Koike; A Nogami; F Murumo; M Hiroe
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

10.  Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.

Authors:  H Fujisaki; H Ito; Y Hirata; M Tanaka; M Hata; M Lin; S Adachi; H Akimoto; F Marumo; M Hiroe
Journal:  J Clin Invest       Date:  1995-08       Impact factor: 14.808
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