BACKGROUND: Phyllodes tumors are classified as benign, borderline, and malignant according to a group of histological features. The expression of many biological markers has been explored to discriminate between different grades of phyllodes tumor and to predict their behavior. The immunohistochemical expression of CD10 has been shown to discriminate between benign and other grades of phyllodes tumor but has not been evaluated as a predictor of metastasis. The purpose of this study was to evaluate the usefulness of immunohistochemical staining of stromal CD10 in predicting the likelihood of metastasis in phyllodes tumors. METHODS: The expression of CD10 was studied in 43 phyllodes tumors (16 benign, 10 borderline, and 17 malignant) using immunohistochemistry to evaluate whether differences in expression correlated with the presence of, and or, development of distant metastasis. RESULTS: Metastasis occurred in six malignant phyllodes tumors. The expression of CD10 significantly (P<0.05) correlated with the occurrence of distant metastasis. CONCLUSIONS: The expression of CD10 can be used to predict the occurrence of distant metastasis in phyllodes tumors of the breast.
BACKGROUND:Phyllodestumors are classified as benign, borderline, and malignant according to a group of histological features. The expression of many biological markers has been explored to discriminate between different grades of phyllodestumor and to predict their behavior. The immunohistochemical expression of CD10 has been shown to discriminate between benign and other grades of phyllodestumor but has not been evaluated as a predictor of metastasis. The purpose of this study was to evaluate the usefulness of immunohistochemical staining of stromal CD10 in predicting the likelihood of metastasis in phyllodestumors. METHODS: The expression of CD10 was studied in 43 phyllodestumors (16 benign, 10 borderline, and 17 malignant) using immunohistochemistry to evaluate whether differences in expression correlated with the presence of, and or, development of distant metastasis. RESULTS: Metastasis occurred in six malignant phyllodestumors. The expression of CD10 significantly (P<0.05) correlated with the occurrence of distant metastasis. CONCLUSIONS: The expression of CD10 can be used to predict the occurrence of distant metastasis in phyllodestumors of the breast.
Authors: Jakub Żurawski; Patrycja Talarska; Mateusz de Mezer; Krzysztof Kaszkowiak; Michał Chalcarz; Katarzyna Iwanik; Jacek Karoń; Piotr Krokowicz Journal: Gastroenterol Hepatol Bed Bench Date: 2022
Authors: Emad A Rakha; Sunil Badve; Vincenzo Eusebi; Jorge S Reis-Filho; Stephen B Fox; David J Dabbs; Thomas Decker; Zsolt Hodi; Shu Ichihara; Andrew H S Lee; José Palacios; Andrea L Richardson; Anne Vincent-Salomon; Fernando C Schmitt; Puay-Hoon Tan; Gary M Tse; Ian O Ellis Journal: Histopathology Date: 2016-01 Impact factor: 5.087
Authors: Fresia Pareja; Felipe C Geyer; Rahul Kumar; Pier Selenica; Salvatore Piscuoglio; Charlotte K Y Ng; Kathleen A Burke; Marcia Edelweiss; Melissa P Murray; Edi Brogi; Britta Weigelt; Jorge S Reis-Filho Journal: NPJ Breast Cancer Date: 2017-10-12