| Literature DB >> 22006254 |
Jing-Jing Cui1, Dong Wang, Fei Gao, Yue-Rong Li.
Abstract
To explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (MMP-9) after intracerebral hemorrhage (ICH) in rats. A rat model of ICH was established by intracerebral injection of collagenase. The brain water content was determined by the wet/dry weight ratio, ultrastructural changes in brain tissue were observed by electron microscopy, and the level of plasma MMP-9 was quantified by ELISA. Atorvastatin showed significant effects in reducing the brain water content, blocking neuron apoptosis, and decreasing plasma MMP-9 in rats with ICH. There was a positive linear correlation between plasma MMP-9 and the brain water content. Atorvastatin can significantly relieve brain edema, decrease the brain injury caused by MMP-9 and protect neurons in rats with ICH.Entities:
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Year: 2012 PMID： 22006254 DOI： 10.1007/s12013-011-9264-7
Source DB: PubMed Journal: Cell Biochem Biophys ISSN： 1085-9195 Impact factor: 2.194