AMPA receptor endocytosis in rat perirhinal cortex underlies retrieval of object memory.

Mechanisms consistent with long-term depression in the perirhinal cortex (PRh) play a fundamental role in object recognition memory; however, whether AMPA receptor endocytosis is involved in distinct phases of recognition memory is not known. To address this question, we used local PRh infusions of the cell membrane-permeable Tat-GluA2(3Y) interference peptide or a scrambled control to block the endocytosis of AMPA receptors during the encoding, consolidation, or retrieval phase of object recognition memory. Tat-GluA2(3Y) infusion before the encoding and consolidation phases did not alter recognition memory. In contrast, Tat-GluA2(3Y) infusion prior to the retrieval phase disrupted object recognition memory. The present results indicate a distinct role for AMPA receptor endocytosis in the retrieval of visual recognition memory.