OBJECTIVES: To determine the long-term health status of donors after right hepatectomy for adult live donor liver transplantation (ALDLT). BACKGROUND: The long-term outcomes for ALDLT donors are unknown. METHODS: ALDLT donors undergoing right hepatectomy from April 1998 to June 2007 were invited to complete a questionnaire regarding health status, satisfaction (1-10/worst-best scale), self-esteem, willingness to donate again, and suggestions for improvement. In addition, donor files and cholecystectomy specimens were reviewed. Fisher's exact test, Kaplan-Meier and logistic regression analyses were performed. RESULTS: Eighty-three donors were contacted (median age: 36 years; median follow-up: 69 months). 39 (47%) were free of symptoms. The remaining 44 (53%) reported: intolerance to fatty meals and diarrhea (31%), gastroesophageal reflux associated with left liver hypertrophy (9%), incisional discomfort requiring pain medications (6%), severe depression requiring hospitalization (4%), rib pain affecting lifestyle (2%), and exacerbation of psoriasis (1%). Median satisfaction score was 8. Self-esteem diminished in 5%. Thirty-nine (47%) recommended improvements particularly more detailed informed donor consent and a centralized living donor liver registry. Seventy-eight (94%) were willing to donate again. There were no differences between donors with and without complaints with respect to: donor age, gender, early complications and follow-up time, young-to-old donation, recipient diagnosis of malignancy and death of the recipient. Noninflamed donor cholecystectomy specimens correlated with intolerance to fatty meals and diarrhea (P = 0.001). CONCLUSIONS: ALDLT donors are at risk for long-term complaints that are neither reflected nor related to early complications. This information should be included in both the donor evaluation and the ALDLT decision-making process.
OBJECTIVES: To determine the long-term health status of donors after right hepatectomy for adult live donor liver transplantation (ALDLT). BACKGROUND: The long-term outcomes for ALDLT donors are unknown. METHODS: ALDLT donors undergoing right hepatectomy from April 1998 to June 2007 were invited to complete a questionnaire regarding health status, satisfaction (1-10/worst-best scale), self-esteem, willingness to donate again, and suggestions for improvement. In addition, donor files and cholecystectomy specimens were reviewed. Fisher's exact test, Kaplan-Meier and logistic regression analyses were performed. RESULTS: Eighty-three donors were contacted (median age: 36 years; median follow-up: 69 months). 39 (47%) were free of symptoms. The remaining 44 (53%) reported: intolerance to fatty meals and diarrhea (31%), gastroesophageal reflux associated with left liver hypertrophy (9%), incisional discomfort requiring pain medications (6%), severe depression requiring hospitalization (4%), rib pain affecting lifestyle (2%), and exacerbation of psoriasis (1%). Median satisfaction score was 8. Self-esteem diminished in 5%. Thirty-nine (47%) recommended improvements particularly more detailed informed donor consent and a centralized living donor liver registry. Seventy-eight (94%) were willing to donate again. There were no differences between donors with and without complaints with respect to: donor age, gender, early complications and follow-up time, young-to-old donation, recipient diagnosis of malignancy and death of the recipient. Noninflamed donor cholecystectomy specimens correlated with intolerance to fatty meals and diarrhea (P = 0.001). CONCLUSIONS: ALDLT donors are at risk for long-term complaints that are neither reflected nor related to early complications. This information should be included in both the donor evaluation and the ALDLT decision-making process.
Authors: Arnold Radtke; George Sgourakis; Ernesto P Molmenti; Susanne Beckebaum; Vito R Cicinnati; Hartmut Schmidt; Heinz-Otto Peitgen; Christoph E Broelsch; Massimo Malagó; Tobias Schroeder Journal: World J Gastroenterol Date: 2015-05-21 Impact factor: 5.742
Authors: Mary Amanda Dew; Zeeshan Butt; Qian Liu; Mary Ann Simpson; Jarcy Zee; Daniela P Ladner; Susan Holtzman; Abigail R Smith; Elizabeth A Pomfret; Robert M Merion; Brenda W Gillespie; Averell H Sherker; Robert A Fisher; Kim M Olthoff; James R Burton; Norah A Terrault; Alyson N Fox; Andrea F DiMartini Journal: Transplantation Date: 2018-01 Impact factor: 4.939
Authors: Alice Tung Wan Song; Vivian Iida Avelino-Silva; Rafael Antonio Arruda Pecora; Vincenzo Pugliese; Luiz Augusto Carneiro D'Albuquerque; Edson Abdala Journal: World J Gastroenterol Date: 2014-05-14 Impact factor: 5.742
Authors: Richard W Laing; Hynek Mergental; Christina Yap; Amanda Kirkham; Manpreet Whilku; Darren Barton; Stuart Curbishley; Yuri L Boteon; Desley A Neil; Stefan G Hübscher; M Thamara P R Perera; Paolo Muiesan; John Isaac; Keith J Roberts; Hentie Cilliers; Simon C Afford; Darius F Mirza Journal: BMJ Open Date: 2017-11-28 Impact factor: 2.692