Literature DB >> 2200429

Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors.

D T Wong1, R W Fuller, D W Robertson.   

Abstract

The biochemical and pharmacological profiles of R,S-fluoxetine and its R and S enantiomers have been compared and reviewed. Both enantiomers exhibit profiles analogous to R,S-fluoxetine as inhibitors of serotonin uptake in vitro and in vivo with about equal potencies or a eudismic ratio near unity.

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Year:  1990        PMID: 2200429

Source DB:  PubMed          Journal:  Acta Pharm Nord        ISSN: 1100-1801


  11 in total

Review 1.  Metabolism and pharmacokinetics of selective serotonin reuptake inhibitors.

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Review 3.  The use of toxicokinetics for the safety assessment of drugs acting in the brain.

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Review 4.  Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism.

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Review 6.  Trends in the development of new antidepressants. Is there a light at the end of the tunnel?

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Review 7.  Chirality and drugs used in psychiatry: nice to know or need to know?

Authors:  R M Lane; G B Baker
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8.  Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain.

Authors:  V Klimek; J Zak-Knapik; M Mackowiak
Journal:  J Psychiatry Neurosci       Date:  1994-01       Impact factor: 6.186

Review 9.  Neural mechanisms of social dominance.

Authors:  Noriya Watanabe; Miyuki Yamamoto
Journal:  Front Neurosci       Date:  2015-06-17       Impact factor: 4.677

10.  A translational rodent assay of affective biases in depression and antidepressant therapy.

Authors:  Sarah A Stuart; Paul Butler; Marcus R Munafò; David J Nutt; Emma Sj Robinson
Journal:  Neuropsychopharmacology       Date:  2013-03-15       Impact factor: 7.853

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