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Literature DB >> 22003436

Cellular and molecular effects of thiazolidinediones on bone cells: a review.

Guillaume Mabilleau, Daniel Chappard, Michel F Baslé.

Abstract

Thiazolidinediones represent a class of molecules used in the treatment of type 2 diabetes mellitus. Despite interesting effects in lowering blood glucose and HbA1c levels durably, an augmentation of the fracture risk in women has emerged in the past years. This review is providing the readers with information about the cellular and molecular mechanisms involved in bone and bone cells in response to these drugs.

Entities: Chemical Disease Species

Keywords: PPARγ; Thiazolidinediones; diabetes mellitus; osteoblast; osteoclast; osteocyte

Year: 2011 PMID： 22003436 PMCID： PMC3193290

Source DB: PubMed Journal: Int J Biochem Mol Biol ISSN： 2152-4114

48 in total

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Authors: Yihong Wan; Ling-Wa Chong; Ronald M Evans
Journal: Nat Med Date: 2007-12-02 Impact factor: 53.440

9. Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma.

Authors: Anna Foryst-Ludwig; Markus Clemenz; Stephan Hohmann; Martin Hartge; Christiane Sprang; Nikolaj Frost; Maxim Krikov; Sanjay Bhanot; Rodrigo Barros; Andrea Morani; Jan-Ake Gustafsson; Thomas Unger; Ulrich Kintscher
Journal: PLoS Genet Date: 2008-06-27 Impact factor: 5.917

Cellular and molecular effects of thiazolidinediones on bone cells: a review.

1. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists.

2. The cellular basis of bone turnover and bone loss: a rebuttal of the osteocytic resorption--bone flow theory.

3. Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage.

4. Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis.

5. Effect of 24R,25-dihydroxyvitamin D3 on the formation and function of osteoclastic cells.

6. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.

7. Systemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice.

8. PPAR-gamma regulates osteoclastogenesis in mice.

9. Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma.

10. The risk of fractures associated with thiazolidinediones: a self-controlled case-series study.

1. Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.

Review 2. Effects of Type 1 Diabetes on Osteoblasts, Osteocytes, and Osteoclasts.

Review 3. Interpreting adverse signals in diabetes drug development programs.

4. Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.